Sophion Bioscience A/s

Qm Technologies Aps

Jonatan Kutchinsky

Rafael Taboryski

Peter Ulrik Kann

Ferdinand Kuemmeth

Morten Bech

Merlin Von Soosten

Anders Kuhle

John Robert Dodgson

John Dodgson

Martin Skjodt

Nicholas Oswald

Bent E Nielsen

Lars Thomsen

John Shaw

Anders Brask

Niels Willumsen

Jørgen Due

Ras Kaas Vestergaard

Jens Henneke

Christopher Mathes

Nicholas Byrne

Dirk Reuter

Martin Skjødt

Anders Kühle

J Rgen Due

Bent Erling Nielsen

Lars c/o Thomsen Bioscience Thomsen

Jorgen Due

A multi-channel filter with a PCB with a first side with signalling tracks and shielding tracks between neighbouring signalling tracks. On the second side, a conductive layer is provided. The signalling tracks are covered by an electromagnetically absorbing material, such as a powder of an electrically conducting material is provided. The filter may have sections with reversed structure where the conductors are on the second side and the layer on the first side, where the conductors on opposite sides are interconnected. The filter may be rolled or folded.

Multi-channel filter comprising plural elongate signal tracks covered by electromagnetically absorbing material and the signal tracks are separated by elongate shielding tracks

A filter comprising a flexible PCB with one or more signal tracks on one side. A electromagnetically absorbing material covers the signal tracks. An insulating material may be provided between the signal tracks and the electromagnetically absorbing material. The PCB is then folded or rolled to take up less space. The PCB may be first folded and then rolled to have both ends of the signal tracks available at the outer portion of the roll.

Rolled or folded filter comprising a flexible printed circuit board having first elongate signal tracks covered by an electromagnetically absorbing material

A chip assembly for use in a microfluidic analysis system, such as a patch clamp apparatus, comprises a chip having an outer wall, a carrier structure comprising an aperture for receiving the chip, the aperture defining an inner wall, wherein the chip is arranged in the aperture with a liquid tight seal between the outer wall of the chip and the inner wall of the aperture. The chip may be sealed and bonded to the carrier structure by means of a bonding material, such as an UV curing adhesive. A through hole in the chip is aligned with the aperture in the carrier structure. A method for manufacturing the chip assembly is further disclosed.

Chip assembly for use in a microfluidic analysis system

A handheld device for analysis of electrophysiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane includes a handheld body with a pump, an electronic controller, and a disposable pipette tip including a pathway for fluid. The pathway connects an open end of the pipette tip to an analysis substrate in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump and the pathway, and to provide an electric connection between the electronic controller and at least one of the electrodes of the substrate. The electronic controller of the handheld body is configured to operate the assembled device for microfluidic analysis of aspirated fluid.

Handheld device for electrophysiological analysis

A microfluidics system comprising a channel having an inlet () and an outlet (); a first membrane () positioned between the inlet () and outlet () and comprising an aperture having a radius within the range 0.1 to 50 &#x3bc;m, the inlet () and the outlet () being in hydraulic communication with one another, such that a fluid can move along the channel from the inlet to the outlet.

Capillary stop

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with the cell membrane, The invention further provides a method of making such a substrate and method for analysing the electrophysiological properties of a cell membrane comprising a glycocalyx.

Substrate and method for measuring the electro-physiological properties of cell membranes

The present invention provides a pump for generating an Electroosmotic Flow (EOF) in a solution in a canal, guide, pipe or equivalent. Electroosmotic flow is generated by application of an electric field through a solution in a canal defined by insulating walls. The phenomenon depends on ionisation of sites on the surface so that for electroneutrality there is an excess mobile charge in the solution. The electric field acts on the excess charge in the solution causing the fluid to flow. The quantity and distribution of excess charge in the solution depends on the solution and the surface materials and is related to a parameter, the zeta (z) potential characterising material/solution combinations.

Corbino disc electroosmotic flow pump

The present invention relates to a high through-put system for determining and/or monitoring electrophysiological properties of ion channels of ion channel-containing membranes, typically lipid membrane-containing structures such as cells. In particular, the invention provides a substrate which provides means for automatically positioning cells at measuring sites using electroosmotic flow in canals formed on or in the substrate. The electroosmotic flow is generated and controlled by electroosmotic flow pumps integrated on the substrate or positioned in relation thereto. Thereby, cells can be positioned in favorable measurement configuration at a plurality of sites for performing testing and measurements. Also, the invention relates to a main electric circuit for performing testing and measurements on a plurality of cells in parallel.

System for electrophysiological measurements

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Ballerup, Denmark

Jonatan Kutchinsky