Novo Nordisk A/s

Jonas Kildegaard Pedersen

Henrik Bengtsson

Tinna Bjoerk Aradottir

Pete Brockmeier

Vera Pinto Glenting

Joern Drustrup

Lars Eilertsen

Jeppe Sturis

Ulla Ribel-Madsen

Rikke Bjerring Andersen

Kezia A Juul

A multi-use drug delivery device for extended use, wherein the multi-use drug delivery device comprising a multi-use main portion () and a single-use flow conducting device () adapted for conducting drug to the subcutaneous tissue of a subject, wherein the change from a connected configuration to an unconnected configuration of the main portion and the flow conducting device is through the intermediate configuration. The intermediate configuration comprises an equalizing channel defining an equalizing flow path () different from an unintended flow path (). The equalizing channel is adapted for equalizing the fluid pressure in a fluid communication volume () to the fluid pressure in the external environment, upon changing the configuration from the connected to the intermediate configuration and thereby expanding an internal volume, whereby an equalizing fluid flow along the equalizing flow path is larger than an unintended flow along the unintended flow path, whereby equalization of the fluid communication volume is provided with a reduced risk of introducing microorganisms from the flow channel () into the reservoir ().

Multi-use drug delivery device for drugs with less preservatives

Systems and methods are provided for optimizing short acting insulin medicament dosage timing relative to a meal event for a subject. Glucose measurements of the subject over a time course and the timing of the measurements are obtained. Meal events in the time course and information regarding when dosages were injected into the subject relative to the meal events is obtained. Bins, each for a different time range for when a dosage is injected relative to a meal event, are constructed. Each bin is assigned glucose measurements in one or more periods within the time course in which the subject injected the dosage within the time range associated with the bin. A glycaemic risk measure is determined for each bin with the assigned measurements and used to identify an optimal relative time range for the subject. This is communicated to a health care practitioner or to the subject.

Systems and methods for optimization of bolus timing relative to meal events

Systems and methods are provided for adjusting a basal/bolus ratio in a standing insulin regimen for a subject that comprises daily amounts of basal and bolus insulin medicaments that define an initial basal/bolus ratio. A data set comprising glucose measurements of the subject with a respective timestamp for each such measurement over a time course is obtained. One or more fasting events are identified in the time course. A temporal glucose gradient is computed for each fasting event using the glucose measurements in the data set within the fasting event time period. Fasting event glucose gradients are used to determine whether to recommend adjustment to the basal/bolus ratio for the subject without change to the daily total insulin medicament. The recommended adjustment to the basal/bolus ratio is communicated when the determination is made to make the recommended adjustment to the basal/bolus ratio for the subject.

Systems and methods for adjusting a basal/bolus ratio in an insulin regimen

An assembly includes a sealed drug reservoir unit, a subcutaneous flow conducting device in the form of a needle unit or an infusion set, and a flow communication unit. The flow communication unit includes a proximal hollow needle adapted to penetrate a needle-penetrable septum of the reservoir, a first flow-way inflow communication with the proximal needle and comprising a pressure-controlled valve, a second flow-way in flow communication with the first flow-way, an amount of preservative arranged to react with a substance received by the second flow-way, and distal flow communication structure adapted to provide flow communication between the second flow-way and the needle unit. The valve is controlled to open when the reservoir is pressurized, the preservative being provided to react with substances introduced to the second flow way via the needle unit.

Flow communication unit with preservative

Systems and methods are provided for optimizing basal administration timing in a standing basal insulin regimen of a subject. The regimen specifies a total amount of basal insulin medicament, one or more basal injection event types for a recurring period, and an apportionment of the total amount of medicament between the injection event types. Time stamped glucose measurements of the subject are obtained over a past time course comprising a plurality of instances of the recurring period. When the glucose measurements satisfy a stop condition, a recommended adjustment is determined that comprises a change in the number of injection event types in the regimen and/or a change in the apportionment of insulin medicament between injection event types. The recommended adjustment is communicated to the subject for manual adjustment of the regimen, an insulin pen charged with delivering the regimen to the subject, or a health care practitioner associated with the subject.

Systems and methods for adjusting basal administration timing

A drug delivery assembly includes a housing (), a piston () axially displaceable in the housing, and a variable volume reservoir () formed by the housing and the piston and containing a fluid first drug. The assembly further includes an exterior fluid inlet () arranged in or configured to be arranged in fluid communication with the reservoir, a fluid outlet () arranged in or configured to be arranged in fluid communication with the reservoir, biasing means () configured for moving the piston forwards, and releasable retaining means () configured for retaining the piston in an initial position, whereby the biasing means is allowed to move the piston forwards to expel fluid drug from the reservoir when the retaining means is released.

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Vaerloese, Denmark

Jonas Kildegaard Pedersen