Swedish Orphan Biovitrum Ab (publ)

Pharmacia & Upjohn Aktiebolag

Swedish Orphan Biovitrum Ab

Jonas Fransson

Ebba Florin-Robertsson

Hans O Himbert

Barry Douglas Moore

Birger Hjertman

Pelle Reinius

Barry D Moore

Diane Moore

A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

Syringe assembly with ion-exchange material

The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.

Compositions comprising anakinra

The present invention relates to a syringe having a barrel, a plunger arranged to travel within said barrel and a plunger rod for driving the plunger in a bidirectional manner. The plunger rod is provided with a head at a distal end thereof and a plurality of protruding finger grip enhancing means axially spaced along a length of the plunger rod.

Syringe plunger rod

The present invention relates to pharmaceutical compositions comprising anakinra as an active compound in the absence of sodium citrate. The said pharmaceutical compositions are useful for the treatment of IL-1 mediated disorders and for decreasing nociceptive pain during such treatment.

Citrate free pharmaceutical compositions comprising anakinra

A device for the serial ejection of at least two fluid components comprises a spacer () providing at least two states, i) a first state allowing a front piston () to be displaced forwards by action on a rear piston () while a fluid volume is retained in a rear chamber () and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.

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Uppsala, Sweden

Jonas Fransson