Johnson & Johnson Consumer Products, Inc.

Bristol-myers Squibb Compnay

Jonas C Wang

Jue-Chen Liu

Mohammed Yusuf

Ying Sun

Stephen J Wisniewski

Hemanshu S Shah

Bhiku Patel

Charles E Clum

Norihiro Yamamoto

Satoshi Kazama

Elizabeth S Kimbleton

Stacley Au

Curtis A Cole

Jean P Holland

Margaret A Aleles

Christopher R Stahl

Kamran Mather

Sachio Hamada

Marilyn Hudson

Chung-Ye Tseng

Elisabeth S Kimbleton

A skin care composition comprising an oil-in-water emulsion and a therapeutically effective amount of a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, the composition having a pH of between about 4 and about 10 and further comprising an oil phase comprising one or more oils having a total unsaturation density, or C value, of about 1200 or less.

Skin care composition comprising a retinoid

There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl containing amino acid or a derivative thereof, the pharmaceutically acceptable salts or esters thereof, or stereoisomers thereof, (2) urea, (1) and (2) being administered in an amount sufficient to enhance the permeation of antifungal drugs through nail tissue, either prior to or, preferably, concurrently with the topical administration to the nail of (3) an effective amount of an antifungal drug. There is also disclosed a bandage adapted for the topical administration of medication to the nail, said bandage comprising a T-shaped adhesive backing, and a flexible pad having an impervious backing and a nail-shaped cavity backed by said impervious backing, wherein said nail-shaped cavity contains absorptive means having absorbed therein urea and a sulfhydryl containing amino acid or a derivative thereof, a pharmaceutically acceptable salt or ester thereof, or a stereoisomer thereof.

Anti fungal treatment of nails

Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.

Composition base for topical therapeutic and cosmetic preparations

Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Topical oil-in-water emulsions containing retinoids

This invention relates to compositions and methods for treating the skin containing retinoids and alpha hydroxy acids such as latic acid, malic acid, fruit acids and sugar-cane-derived acids, for mitigating the irratating effects of retinoids on the skin.

Retinoid composition

Antifungal treatment of nails

Skin care compositions comprising a water-in-oil emulsion base containing retinoids and possessing good physical and chemical stability.

Retinoid compositions containing a water soluble antioxidant and a

This invention relates to skin care compositions containing retinoids which are generally applied topically to improve the quality of the skin. More particularly, this invention relates to skin care compositions comprising retinol (Vitamin A alcohol) and further comprising irritation ameliorating quantities of glycolic acid.

Skin care compositions comprising a water-in-oil emulsion base containing retinoids and at least one imidazole in a free base form and possessing good physical and chemical stability.

Retinoid containing skin care compositions containing imidazoles

Skin care compositions comprising a water-in-oil emulsion base containing retinoids and possessing good physical and chemical stability. The retinoids suitable for use in these skin care compositions include Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof.

Skin care compositions containing retinoids

A personal lubricant composition containing an antiviral, alkylphenoxypolyethoxyethanol spermicide, a water soluble polymer gel matrix and a solubilizer which permits the spermicide to be compatible with the gel matrix. Preferably, a polyethoxylated compound such as polyethoxylated castor oil may be used.

Spermicidal anti-viral lubricant composition and method of using same

A shampoo that contains ketoconazole, a surfactant, a foaming agent, thickener sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps at room temperature (i.e., about 20.degree.-25.degree. C.), preservative, butylated hydroxytoluene or butylated hydroxyanisole in an amount sufficient to retard degradation of the ketoconazole, and acid, base or buffer sufficient to give the final composition a pH in the range of from about 4 to about 10.

Ketoconazole shampoo containing butylated hydroxytoluene or butylated

Stable anhydrous gel formulations for topical antifungal use contain an imidazole, a steroid, a co-solvent system comprising monohydric and dihydric alcohols, and a hydroxyalkylcellulose gellant.

Antifungal gel formulations

This invention relates to an anthralin composition having improved stability. The invention further relates to a method for increasing the stability of anthralin in dermatological compositions by incorporating therein a stability enhancing amount of an acid stable anionic surfactant and a water soluble antioxidant.

Compositions and method for stabilization of anthralin comprising the

An antifungal gel composition, effective at 0.2-2.0% by weight of an imidazole antifungal agent and 0.01-2.5% by weight of a 17-ester corticosteroid antiinflammatory agent, is provided for topical administration. This composition is highly effective in treating fungal infections and is capable of being stored without refrigeration for long periods of time without losing therapeutic effectiveness and while maintaining the uniformity and stability of the gel.

Growing community of inventors

Robbinsville, NJ, United States of America

Jonas C Wang