Amgen Research (munich) Gmbh

Amgen Inc.

Amgen Research Gmbh

Jonas Anlahr

Peter Kufer

Tobias Raum

Patrick Hoffmann

Doris Rau

Ralf Lutterbüse

Andreas Wolf

Claudia Blümel

Benno Rattel

Christoph Dahlhoff

Bertram Weiss

Elisabeth Nahrwold

Cornelius Pompe

Johannes Brozy

Matthias Friedrich

Markus Muenz

Pamela Bogner

Lisa Nahrwold

Ruprecht Zierz

Julie Bailis

Claudia Bluemel

Anna-Lena Frisk

Ann-Lena Frisk

Ralf LUTTERBÜSE

Claudia BLÜMEL

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Bispecific antibody constructs for CDH3 and CD3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Antibody constructs for MSLN and CD3

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

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Munich, Germany

Jonas Anlahr