Bristol-myers Squibb Compnay

Jonas A Gylys

Edward H Ruediger

Joseph P Yevich

Ronald J Mattson

David W Smith

Charles P Sloan

Joseph A Cipollina

Carola Solomon

Pierre Dextraze

A series of novel serotonergic indolyl derivatives of cycloalkanyl- and cycloalkenyl-amines of Formula I are intended for use in the alleviation of vascular headaches. ##STR1##

Antimigraine derivatives of indolylcycloalkanylamines

A series of novel 5-cyclobutenedione derivatives of indolylalkylpiperazinyl pyridines and pyrimidines of Formula I are intended for use in the alleviation of vascular headaches. ##STR1##

Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and

A series of serotonergic 5-cyclobutenedionylamino-substituted tryptamine derivatives of Formula I is disclosed for use in the alleviation of vascular headaches. ##STR1## The formula I substituents, as further defined in the specification, are: R.sup.1 is hydrogen, halogen, and alkyl; R.sup.2 and R.sup.3 can be hydrogen or alkyl; R.sup.4 is hydrogen, alkyl, acyl or alkylsulfonyl; m is 0 to 3 and n is 1 to 5; and X is amino, alkoxy, hydrogen, alkyl, aryl or alkylaryl.

Antimigraine cyclobutenedione derivatives of tryptamines

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Jonas A Gylys