Boehringer Ingelheim International Gmbh

Abexxa Biologics, Inc.

The University of Texas System

Boehringer Ingelheim Pharmaceuticals, Inc.

Jon Weidanz

Katherine Upchurch-Ange

Georgios Alexandrakis

Sai Santosh Sasank Peri

Muhammad Usman Raza

Provided herein are antibodies that selectively bind to complex comprising a non-classical HLA-I (e.g. HLA-E) and a neoantigen having variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions (CDRs) as disclosed herein, as well as methods and uses thereof.

Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use

In one aspect, molecular sensors and methods of making molecular sensors are described herein. In some embodiments, such a sensor comprises a first layer having a dual nanohole structure and a second layer having at least one nanopore. In some embodiments, the first and second layer define a chip of the sensor. In another aspect, methods of sensing are described herein, which in some embodiments comprise (i) providing a test sample comprising complexed and/or non-complexed biomolecules; (ii) contacting the test sample with the first layer of the molecular sensor; (iii) irradiating the dual nanohole structure of the sensor with a beam of electromagnetic radiation; (iv) optically trapping the biomolecules in the dual nanohole structure and measuring a surface plasmon resonance; (v) applying an electric field across the nanopore of the sensor; and (vi) measuring change in current across the nanopore during one or more translocation events of the biomolecules.

Nanosensors and methods of making and using nanosensors

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Arlington, TX, United States of America

Jon Weidanz