Thia Medica As

Jon Songstad

Rolf Kristian Berge

Leiv K Sydnes

The present invention relates to novel fatty acid analogous of the general formula (I): R&#x2014;[x&#x2014;CH]&#x2014;COORwherein Ris: a C-Calkene with one or more double bonds and/or with one or more triple bonds, and/or a C-Calkyne, and/or a C-Calkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C-Calkoxy, C-Calkylthio, C-Cacyloxy or C-Calkyl, and wherein R2 represents hydrogen or C-Calkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and with the proviso that at least one of the Xis not CH, and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (&#x3c9;-1) carbon and the (&#x3c9;-2) carbon, or between the (&#x3c9;-2) carbon and the (&#x3c9;-3) carbon, or between the (&#x3c9;-3) carbon and the (&#x3c9;-4) carbon, a salt, prodrug or complex thereof, which can be used for the treatment and/or prevention of syndrome X, obesity, hypertension, fatty liver, diabetes, hyperglycaemia, hyperinsulinemia and stenosis. Further, the invention relates to a nutritional composition comprising said fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal.

Growing community of inventors

Bergen, Norway

Jon Songstad