Cellectricon Ab

Jon Sinclair

Daniel T Chiu

Owe Orwar

Mattias Karlsson

Johan Pihl

Kent Jardemark

Jessica Olofsson

Cecilia Farre

The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a large number of different solution environments whose characteristics may be known or unknown.

Systems and methods for rapidly changing the solution environment around sensors

The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying receptors.

Systems and method for rapidly changing the solution environment around sensors

The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.

System and method for obtaining and maintaining high-resistance seals in patch clamp recordings

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Göteborg, Sweden

Jon Sinclair