The Johns Hopkins University

Jon R Resar

George L Coles

Morgana M Trexler

Jason J Benkoski

Chao-Wei Hwang

Hala J Tomey

Robert C Matteson, Iii

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

Method of manufacturing an implantable pressure-actuated drug delivery system

Methods of manufacture and use of implantable pressure-actuated drug delivery systems

Growing community of inventors

Stevenson, MD, United States of America

Jon R Resar