Monsanto Company

Jon P Schaumann

Joseph Feder

Jitka V Olander

Nicholaos K Harakas

Daniel T Connolly

Arthur J Wittwer

Nicholaos K Hrakas

Plasminogen activators (PA) are obtained from cultured normal human colon cells which are adaptable to large scale production. A purified tissue PA (t-PA) is obtained from CCD-18Co normal human colon fibroblast cells which shows chemical differences from Bowes melanoma t-PA.

Large scale production of plasminogen activator from normal human colon

A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.

Monoclonal antibody specific for human colon fibroblast-derived t-PA

Monoclonal antibody specific for human colon fibroblast-derived T-PA

Growing community of inventors

Kirkwood, MO, United States of America

Jon P Schaumann