Ethicon, Gmbh

Battelle Memorial Institute

Johnson & Johnson Medical Gmbh

Johnson & Johnson Medical Div Ethicon, Inc.

Jon Morrell Jacobs

Szu-Min Lin

Paul Taylor Jacobs

Tralance O Addy

Richard Dale Smith

Harold R Williams

Anthony Lemus

Erin M Baker

Thomas O Metz

Kristin E Burnum-Johnson

David G Camp, Ii

Marina A Gritsenko

Daniel Orton

Wei-Jun Qian

Weijun Qian

Ashoka D Polpitiya

Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

Biomarkers for liver fibrosis

A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.

Serum markers for type II diabetes mellitus

A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.

Method for identifying type I diabetes mellitus in humans

A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized. Alternatively, the sterilization method may include introducing germicide vapor into an attachable/detachable container.

Method for sterilizing devices in a container

A sterilized article is within the interior of a diffusion-restricted container. The container substantially prevents entry of microorganisms into the interior thereof. The container has at least one entry/exit port which permits entry/exit of gas and/or vapor into/out of the interior, but prevents entry of microorganisms into the interior.

Sterilized device in diffusion-restricted container

A sterilized article is within the interior of a diffusion-restricted container. The container substantially prevents entry of microorganisms into the interior thereof. The container has at least one communication port which permits entry of gas and/or vapor into the interior, but prevents entry of microorganisms into the interior.

Sterilized article within diffusion-restricted containers

A method for sterilizing an article in a diffusion restricted container includes placing the article in a diffusion restricted container with at least one communication port, placing the container in a vacuum chamber, introducing a vaporizable germicide into the container, and reducing the pressure in the vacuum chamber, generating germicide vapor and sterilizing the article. The article to be sterilized can be a diffusion restricted device, such as a hinge, a mated surface, or a lumen. The germicide may be peroxide or peracetic acid.

Method for sterilizing an interior of an article

A method for sterilizing an interior of an article with a diffusion-restricted area therein includes the steps of contacting the interior of the diffusion-restricted area with a source of peroxide, and exposing the device to negative pressure for a time period sufficient to effect complete sterilization of the diffusion-restricted area.

A method for hydrogen peroxide vapor sterilization of medical devices and similar instruments having long narrow lumens or diffusion restricted areas includes the step of pretreating the article to be sterilized with a dilute solution of hydrogen peroxide prior to exposure to a vacuum or a vacuum followed by plasma. The method is such that, upon vaporization of the solution caused by the vacuum, the hydrogen peroxide remains in contact with the article for a time sufficient to achieve sterilization.

Method of sterilization using pretreatment with hydrogen peroxide

Methods for peroxide vapor sterilization of medical devices and similar instruments having long narrow lumens or diffusion restricted areas includes the step of contacting the article to be sterilized or a diffusion-restricted environment containing said article with a source of peroxide prior to exposure to a vacuum or a vacuum followed by plasma. The methods are such that, upon vaporization of the source of peroxide caused by the vacuum, the peroxide remains in contact with the article for a time sufficient to achieve sterilization.

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Trabuco Canyon, CA, United States of America

Jon Morrell Jacobs