University of Pennsylvania

University of Florida Research Foundation, Incorporated

Jon Lindstrom

William Reade Kem

Ferenc Soti

Hong Xing

Anne Rouchaud

Jie Luo

Kristin Marie Andrud

In one embodiment a vaccine composition comprises two or three AChR subunit constructs and an adjuvant. In some embodiments the AChR subunit construct is an AChR &#x3b1;1 subunit construct, an AChR &#x3b2;1 subunit construct, an AChR &#x3b3; subunit construct, an AChR &#x3b4; subunit construct, or an AChR &#x3b5; subunit construct. In another embodiment, the invention provides a method of treating myasthenia gravis in a patient in need thereof, comprising administering a vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of AChR &#x3b1;1 subunit, AChR &#x3b2;1 subunit, AChR &#x3b3; subunit, AChR &#x3b4; subunit, AChR &#x3b5; subunit, a fragment thereof, and a combination thereof, and an adjuvant.

Acetylcholine receptor-specific immunosuppressive compositions and methods of treatment of myasthenia gravis

Embodiments of the present disclosure provide for compounds such as those shown in FIG.(compounds A, B, C, and D), 2'substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG., compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2&#x2032;substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like. 

Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use

Growing community of inventors

Radnor, PA, United States of America

Jon Lindstrom