Memorial Sloan Kettering Cancer Center

Juno Therapeutics Gmbh

Jon Jones

Eric L Smith

Yan Chen

Steven M Shamah

Csaba Pazmany

Semih Ullah Tareen

Jui Dutta-Simmons

Rupesh Amin

Blythe D Sather

Collin Hauskins

Melissa Works

Aye Chen

Michael Ports

Kimberly Harrington

Ruth Salmon

Rebecca Wu

Erik Hess

Cyr De Imus

Audrey Olshefsky

Timothy G Johnstone

Stefan Ponko

Ronald James Hause, Jr

Mariana Cota Stirner

Oleksandr Baturevych

David G Kugler

Neha Soni

Provided herein are chimeric receptors, including chimeric antigen receptors (CARs), comprising BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof, including heavy chain variable (V) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, including a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof including in adoptive cell therapy.

Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides

Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (V) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

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Seattle, WA, United States of America

Jon Jones