Somalogic Operating Co., Inc.

Jon H Monserud

Jason Paul Cleveland

Maarten Rutgers

Rachel Woolaver Trahan

Stephan Kraemer

Barry Patrick John Vant-Hull

Barry Vant-Hull

Robert T Scribner

Alex Kislukhin

Array plates in accordance with the present teachings may include: a perforated cover plate defining a plurality of first apertures, a supportive base plate defining a planar surface, and a gasket sandwiched between the perforated cover plate and the supportive base plate. Array plates are configured to support a slide, such that the slide is sandwiched between the gasket and the supportive base plate. In some examples, an array plate system in accordance with the present teachings includes a slide ejection tool and/or a gasket installation tool.

Assay array plate

Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection are disclosed herein. The methods include positioning, within the given subarray, a sample solution, which includes dissolved sample molecules (DSMs) that define a dissolved sample oligonucleotide sequence and dissolved leak detection molecules (DLDMs) that define a predetermined dissolved leak detection oligonucleotide sequence. The methods also include detecting the DLDMs within a region of the microarray chip that is external the given subarray. The kits of components include the microarray chip and DLDMs. The microarray chips includes a plurality of subarrays and a leak detection region that is at least partially external the plurality of subarrays.

Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection

Systems and methods for conducting surface-mediated chemical and/or biochemical reactions within an enclosed chamber are disclosed. Systems and methods of the present disclosure may be used in conducting hybridization reactions of biopolymers. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the direction of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing and the direction of mixing at least once over the course of a reaction.

Method for conducting uniform reactions

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Golden, CO, United States of America

Jon H Monserud