Clinical Micro Sensors, Inc.

California Institute of Technology

Osmetech Technology, Inc.

Genmark Diagnostics, Inc.

Osmetch Technology, Inc.

Other

Roche Molecular Systems, Inc.

Advanced Liquid Logic, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Jon Faiz Kayyem

Thomas J Meade

Stephen D O'Connor

Scott E Fraser

Changjun Yu

Sean Ford

Robert H Terbrueggen

Dominic Aiello

David W Wright

Brian P Murphy

Vamsee K Pamula

Eric D Schneider

Michael Gozin

Gary T Olsen

Jayashankar Srinivasan

Darren S Gray

Vijay Srinivasan

Mathieu Dominic Turpault

Frederic Zenhausern

Tyler David Jensen

George Maltezos

Gary Fife Blackburn

Hau H Duong

Robert Pietri

Peter Kroehl

Jost G Vielmetter

Bruce D Irvine

Christopher John Murray

Piotr Grodzinski

Scott Corey

Cynthia C Bamdad

Jay Srinivasan

Andrew Fish

Claudia C Argueta

William Bender

Daniel A Litvack

Javier Gonzalez

Edward Lewis Sheldon, Iii

Ken Rusterholz

Matthew Sean Thomas

Bradford Frederick Tieman

David Walter Wright

Darren Scott Gray

Brian Murphy

This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.

Integrated multiplex target analysis

Instrument

Biochip cartridge

In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation

The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.

Methods for the electrochemical treatment of self-assembled monolayers

Cartridge for performing assays in a closed sample preparation and reaction system

The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.

Use of microfluidic systems in the electrochemical detection of target analytes

The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Electronic methods for the detection of analytes

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Nucleic acid mediated electron transfer

Growing community of inventors

Pasadena, CA, United States of America

Jon Faiz Kayyem