Photocure Asa

Jon Erik Brænden

Jo Klaveness

Stephan D Parent

Aslak Godal

Nils Olav Nilsen

Colin Barry Charnock

The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: whereinRrepresents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group;R, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; andX is a linking group.

Carboxylic acid ALA esters

This invention relates to a novel crystalline polymorph of hexyl-5-aminolevulinate hydrochloride, referred to hereinafter as Form C, which is useful as precursor of a photo sensitizer in the photodynamic diagnosis and treatment of metabolically active cells related to diseases such as cancer of the uterus, cervix, vagina, rectum, colon, lower gastrointestinal tract; infection associated with cancer caused by human papilloma virus; non-cancerous lower gastrointestinal tract a human; inflammatory bowel disease; ulcerative colitis; Crohn's disease; inflammatory bowel syndrome; dysplasia of the female reproductive system; anus; penis; rosacea; and acne and which is suitable for use as the active ingredient of a commercial pharmaceutical product. The invention relates further to methods of preparing Form C and using it in the described pharmaceutical compositions.

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Oslo, Norway

Jon Erik Brænden