Photocure Asa

Jon Erik Braenden

Jo Klaveness

Aslak Godal

Nils Olav Nilsen

Johan E Moan

Qian Peng

Trond Warloe

Harald Steen

Karl E Gierskcky

Alf Bjorseth

Bjorn Klem

Gry Stensrud

The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

Acid addition salts of 5-aminolevulinic acid or its derivatives

The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention provides compounds of formula (I): RN&#x2014;CHCOCHCHCO&#x2014;OR(wherein Rrepresents an optionally substituted branched alkyl (e.g. Calkyl) group, or a substituted alkyl group; R, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group, preferably a group R; wherein said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo, fluoro, &#x2014;SR, &#x2014;NRand PRgroups, and each alkyl group is optionally interrupted by one or more O&#x2014;, &#x2014;NR&#x2014;, &#x2014;S&#x2014; or &#x2014;PR&#x2014; groups; and Rrepresents a hydrogen atom or a Calkyl group) and salts thereof for us in diagnosis and photochemotherapy of disorders of abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) RN&#x2014;CHCOCH&#x2014;CHCO&#x2014;OR(wherein Rmay represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and Rrepresents a hydrogen atom or a group R, and both Rgroups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy

The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention provides compounds of formula (I): RN&#x2014;CHCOCHCHCO&#x2014;OR(wherein Rrepresents an optionally substituted branched alkyl (e.g. Calkyl) group, or a substituted alkyl group; R, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group, preferably a group R; wherein said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo, fluoro, &#x2014;SR, &#x2014;NRand PRgroups, and each alkyl group is optionally interrupted by one or more O&#x2014;, &#x2014;NR&#x2014;, &#x2014;S&#x2014; or &#x2014;PR&#x2014; groups; and Rrepresents a hydrogen atom or a Calkyl group) and salts thereof for use in diagnosis and photochemotherapy of disorders of abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Growing community of inventors

Oslo, Norway

Jon Erik Braenden