Schering Corporation

Jon E Clark

Doris P Schumacher

Bruce L Murphy

Guang-Zhong Wu

Process for preparing florfenicol, its analogs and oxazoline

A novel process for regioselectively preparing oxazoline compounds is disclosed. The process utilizes an amino alcohol, a cyano compound, a base and a dihydric alcohol solvent, a polyhydric alcohol solvent or mixtures thereof.

Process for preparing oxazoline compounds

There is disclosed a high yielding process for converting a hydroxy alkyl oxazolidine compound to the corresponding fluoro derivative by reacting the hydroxy compound with .alpha., .alpha.-difluoroalkylamine under pressure.

Pressurized fluorination of hydroxy alkyl groups

Compounds of the formula: ##STR1## are produced, with the variables as indicated within.

3-phenethyl-2-benzene-amides or aza-derivatives thereof

Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.

Antihistaminic fluoro substituted benzocycloheptapyridines

A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.

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Highland Park, NJ, United States of America

Jon E Clark