Harvard College

Massachusetts Institute of Technology

University of California

Genzyme Corporation

Wisconsin Alumni Research Foundation

University of Washington

Children's Medical Center Corporation

Universidad De Costa Rica

Jon Clardy

Cassandra Celatka

Michael A Fischbach

Renato Tony Skerlj

Dyann F Wirth

Roger Wiegand

Joseph Cortese

Ralph Mazitschek

Cecilia M Bastos

Yibin Xiang

Christopher A Voigt

Jeffrey A Bluestone

Cameron Robert Currie

E Peter Greenberg

Paula I Watnick

Thomas Wyche

Shugeng Cao

Mary Lynn Baniecki

Fang-Yuan Chang

Michael L Booker

Chun-Jun Guo

Ethan Van Arnam

Joshua Alan Blodgett

Patricia Silva Lima

Breck Duerkop

Josephine R Chandler

Clarissa Sit

Vishal P Patel

Laura Brown

Elyse M J Bourque

Antonio Ruzzini

Sameer Urgaonkar

Adrian Alberto Pinto-Tomas

Rebecca Case

Roberto Kolter

Cristina Penaranda

Patrick Ymele-Leki

Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.

Compositions and methods for modulating protease activity

Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claims.

Antifungal compounds

Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.

Glycosphingolipids for use in modulating immune responses

Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV): or a pharmaceutically acceptable salt thereof.

Natural product antibiotics and analogs thereof

Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae. Provided are compounds having algicidal activities and methods of use of these compounds as well as formulations and compositions comprising the compound having algicidal activities.

Roseobacticides and uses thereof

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)&#x2014;The values and preferred values of the variables in Structural Formula I are defined herein. 

2-aminoindole compounds and methods for the treatment of malaria

Inhibitors of dihydroorotate dehydrogenase (DHODH) for theenzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.

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The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in(bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as astrain comprising a bta cluster (e.g.(e.g. E264, Bt4, and TXDOH) and(e.g. K96243, 1106a, and 1106b).

Bactobolin analog and synthesis method thereof

Growing community of inventors

Jamaica Plain, MA, United States of America

Jon Clardy