Other

Myriad Genetics, Inc.

Myriad Pharmaceuticals, Inc.

Manfredi, John

Jon Adam Willardsen

Rachel M Slade

Mark B Anderson

Warren S Weiner

Ruth J Walton

Kenton Zavitz

Yevgeniya Klimova

Robert J Halter

Ashantai J Yungai

John P Manfredi

Christine A Klein

Ashok Bajji

Andrew Gassman

Eric Delmar

Leena Bhoite

Esther Arranz

Jayasree M Srinivasan

Rachel Slade

The present disclosure relates to novel indole and tetrahydroindole core compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport).

Compounds for Alzheimer's disease

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(&#x2550;O)OH, -L-CH&#x2550;CHC(&#x2550;O)OH, -L-C(&#x2550;O)NH, -L-C(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)(Calkyl), -L-S(&#x2550;O)NH, -L-S(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)NHOH, -L-C(&#x2550;O)CHNH, -L-C(&#x2550;O)CHOH, -L-C(&#x2550;O)CHSH, -L-C(&#x2550;O)NHCN, -L-NHC(&#x2550;O)OR, -L-C(&#x2550;O)NHR, -L-NH(C&#x2550;O)NHR, -L-C(&#x2550;O)N(R), -L-NH(C&#x2550;O)N(R), -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

Compounds for alzheimer's disease

Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases.

Compounds, compositions, and methods employing same

Growing community of inventors

Sandy, UT, United States of America

Jon Adam Willardsen