Altor Bioscience Corporation

The Scripps Research Institute

Sunol Molecular Corporation

Weidanz, Jon A.

Wittman, Vaughan P.

Jon A Weidanz

Hing C Wong

Peter Rhode

Jin-an Jiao

Peter R Rhode

Kimberlyn F Card

Linda A Sherman

Pierre-Andre Chavaillaz

Heather J Belmont

Norman R Klinman

Elizabeth L Thomson

Susan Grammer

Ana C Edwards

Ann C Edwards

The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.

Polyspecific binding molecules and uses thereof

The invention provides T-cell receptor (TCR) molecules comprising a V&#x3b1; chain and a V&#x3b2; chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.

P53 binding T cell receptor molecules

The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.

MHC complexes and uses thereof

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Miami, FL, United States of America

Jon A Weidanz