Terumo Bct, Inc.

Terumo Bct Biotechnologies, LLC

Other

Jon A Dodd

Glen Delbert Antwiler

Casey V Medina

Michael E Kinzie

Edward Allan Stanton, Iv

Patrick J Howley

Thomas G Dilorenzo

Dennis J Hlavinka

Brian J Nankervis

Haralambos P Apostolopoulos

Daniel R Clement

Jeremy T Parsons

Monique Givens

Paul M Leuthaeuser

Kristina E Fuerst

Frank Corbin, Iii

Mark E Jones

John Kearns, Iii

Stanley Liang Chen

Daniel Adam Godrick

Daniel Russell Clement

Edward Allan Iv Stanton

Frank Iii Corbin

Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

Flow cell

Fluid flow-through

Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system

Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.

Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system

Embodiments for loading and expanding particular cell types are described. Embodiments may include the use of hollow fiber membranes with particular characteristic such as hollow fibers with inner diameters that provide mechanical stimulus (e.g., radius of curvature greater than a dimension of a cell). In addition, embodiments may provide for manipulation of flow rates and other features that also provide mechanical stimuli and promote or enhance the growth of particular types of cells.

Cell growth with mechanical stimuli

Embodiments are described that relate to flow rate measuring systems that may be used in cell expansion systems (CES) and in methods for controlling fluid input into systems such as a CES.

Measuring flow rate

Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.

Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions

A sleep system includes a sleep surface with a customized profile. The profile of the sleep surface is particularly and specifically designed to maintain a proper sleeping position for an individual. The sleeping surface can include two or more portions that have configurations that ensure the straight alignment of the spine for a person sleeping on the sleep surface. This type of sleep system is customized to each person and, thus, provides a beneficial sleeping position that is individualized and provides the best support for the particular sleeper.

Configurable bed

A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.

Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith

Growing community of inventors

Littleton, CO, United States of America

Jon A Dodd