Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Jolan Hercsel Nee Szepespataky

Laszlo Feuer

Arpad Furka

Ferenc Sebestyen

Erzsebet Bendefy Nee Dobay

A process for preparing gamma-L-glutamyl-taurine, which has been found to be effective therapeutically through the control of vitamin A metabolism, which comprises reacting carbobenzyloxy-L-glutaminic acid-.alpha.-benzyl ester with triethylamine and isobutylchloroformate and then treating the reaction mixture with cystamine dihydrochloride to recover N,N'-bis-(N-carbobenzyloxy-gamma-[.alpha.-benzyl]-L-glutamyl)-cystamine. The latter is reacted with hydrogen peroxide in glacial acetic acid to produce carbobenzyloxy-gamma-(.alpha.-benzyl)-L-glutamyl taurine. The latter compound is treated with hydrogen bromide in glacial acetic acid to recover the gamma-(.alpha.-benzyl)-L-glutamyl taurine and this compound is treated with potassium hydroxide solution to yield the gamma-L-glutamyl taurine.

Method of preparing gamma-L-glutamyl taurine

Gamma-L-glutamyl cholamine phosphate and beta-L-aspartyl cholamine phosphates are disclosed, the compounds having blood-sugar-level lowering and serum vitamin A increasing effect.

Growing community of inventors

Budapest, Hungary

Jolan Hercsel Nee Szepespataky