Inflazome Limited

Jokin Carrillo Arregui

David Miller

Matthew Cooper

Jonathan Shannon

Angus Macleod

Stephen Thom

Stuart Thomas Onions

Jimmy Van Wiltenburg

Stephen St-Gallay

Ian Strutt

Thomas Alanine

Jochem Theodoor Van Herpt

The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered heteroaryl group substituted with a monovalent heteroaryl-containing group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP.

Sulfonamide carboxamide compounds

The present invention relates to compounds of formula (I): wherein Q is selected from O or S; Rand Rare each independently hydrogen or an optionally substituted hydrocarbyl group, or Rand Rtogether with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and Ris a cyclic group substituted at the position, wherein Rmay optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Sulfonamideurea compounds

The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with a nitrogen-containing group R' wherein Rcontains from 1 to 7 atoms other than hydrogen or halogen. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP.

Sulfonylureas and sulfonylthioureas as NLRPinhibitors

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Nottingham, United Kingdom

Jokin Carrillo Arregui