Toyama Chemical Co., Ltd.

Joji Nakano

Isamu Saikawa

Chosaku Yoshida

Takako Hori

Hisatsugu Tsuda

Shohachi Murakami

Ryuko Takeno

Yasuo Kiba

Jun Nitta

Sumiko Kishimoto

Toru Hiraiwa

Kaishu Momonoi

Isao Watanabe

Satoshi Ono

Kenji Takeda

Katsuyuki Nagumo

Hiroyo Kawafuchi

Hiroyasu Takagi

Makoto Takata

Kunikazu Furuhata

Tetsuo Yamafuji

Hisaaki Chaki

Hisashi Minami

Nobuo Terashima

Nobuhisa Taya

Tadakazu Takakura

Mineichi Sudani

Toyokazu Kobayashi

1,2-benzoisoxazole derivative or its salt and brain-protecting agent

This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R.sup.2 represents a hydrogen atom or a hydroxyl-protecting group and R.sup.4 and R.sup.5, which may be the same or different, represents lower alkyl groups, using a compound represented by formula (2a) or (2b) obtained by preferential crystallization: ##STR2## and also to a compound represented by the following formula (7) which is an intermediate useful for producing the compound of formula (6a) or (6b): ##STR3## wherein R.sup.1 represents a group represented by formula (8): ##STR4## wherein R.sup.2 and R.sup.3 is as defined above and R.sup.3 represents a hydrogen atom, a group or a carboxyl protecting group represented by formula (9): ##STR5## or a group represented by formula (10): ##STR6## wherein R.sup.2 is as defined above.

Benzo[b]thiophen-5-yl derivative and process for producing the same

A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.

Piperazine derivative or its salt, process for producing the same and

This invention relates to a novel 1,4-dihydropyridine derivative of the formula ##STR1## wherein R2 is pyridyl, or a salt thereof. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity. Also disclosed are pharmaceutical compositions containing the same.

Pyridyl ester containing 1,4-dihydropyridine derivatives and salts

This invention relates to a 1,4-dihydropyridine derivative of the formula ##STR1## wherein Y represents an oxygen or sulfur atom or a vinylene group, Z represents an oxygen or sulfur atom or an alkylene group, R.sup.2 represents an imidazolyl or pyridyl group and the remaining substituents are herein defined. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity.

Vasodilating and platelet aggregation inhibiting 1,4 dihydropyridines

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition salts

Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or acid

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and a salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts thereof

4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, acid

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Toyama, Japan

Joji Nakano