Rhone-Poulenc Chimie

Rhone-Poulenc Sante

Johnny Haggiage

Ghislaine Torres

Alain Fisch

Thierry Prazuck

Hugues Porte

Guy Cyprien

Christian Pusineri

Cyprien Guy

Huges Porte

Silicone dosage forms adapted for the continuous and controlled release of iodine values, notably to domestic water supplies for the treatment of the various disease states attributed to iodine deficiency, are shaped from (A) a diorganopolysiloxane matrix resin; (B) a reinforcing amount of a filler material (B.sub.1) therefor and/or an organic peroxide (B.sub.2); and (C) a therapeutically effective amount of at least one water soluble, nontoxic, organic and/or inorganic iodine compound which is in solid or liquid state at ambient temperature.

Diorganopolysiloxane dosage forms for the controlled release of iodine

Polycondensation silicone elastomer dosage forms adapted for the continuous and controlled release of iodine values, notably to domestic water supplies for the treatment of the various disease states attributed to iodine deficiency, are shaped from (A) at least one diorganopolysiloxane oil bearing at least two condensable or hydrolyzable groups, or a single hydroxyl group, at each end of the polymer chain; (B) a therapeutically effective amount of at least one water soluble, nontoxic, organic and/or inorganic iodine compound which is in solid or liquid state at ambient temperature and which does not inhibit curing of the composition into an elastomer; (C) a catalytically effective amount of a polycondensation catalyst; and optionally, (D) a silane containing at least three condensable or hydrolyzable groups.

Polycondensation silicone elastomer dosage forms for the controlled

Heat-vulcanized silicone dosage forms adapted for the continuous and controlled release of iodine values, notably to domestic water supplies for the treatment of the various disease states attributed to iodine deficiency, are shaped from (A) a diorganopolysiloxane matrix resin containing at least two vinyl groups bonded to silicon per molecule and having a viscosity of at least 500,000 mPa.s at 25.degree. C.; (B) at least one organohydropolysiloxane containing at least three hydrogen atoms bonded to silicon per molecule; (C) a reinforcing amount of a filler material therefor; (D) a catalytically effective amount of a platinum group metal catalyst; and (E) a therapeutically effective amount of at least one water soluble, nontoxic, organic and/or inorganic iodine compound which is in solid or liquid state at ambient temperature.

Polyaddition silicone elastomer dosage forms adapted for the continuous and controlled release of iodine values, notably to domestic water supplies for the treatment of the various disease states attributed to iodine deficiency, are shaped from (A) at least one organopolysiloxane containing at least two vinyl groups bonded to silicon per molecule; (B) at least one organopolysiloxane containing at least three hydrogen atoms bonded to silicon; (C) a catalytically effective amount of a platinum group metal compound; and (D) a therapeutically effective amount of at least one water soluble, nontoxic, organic and/or inorganic iodine compound which is in solid or liquid state at ambient temperature and which does not inhibit the catalytic activity of the platinum group metal compound (C).

Polyaddition silicone elastomer dosage forms for the controlled release

New transdermal medicaments comprise the active ingredient dispersed in a heat-reversible, non-crosslinked, film-forming, homogeneous polymer optionally with a non-ionic emulsifier and, if appropriate, a hydrophobic, water-insoluble copolymer.

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Lyons, France

Johnny Haggiage