Harvard College

Dana-farber-cancer Institute Inc.

T Cell Sciences, Inc.

Other

Johnathan Seidman

Jack L Strominger

Michael B Brenner

Stephen H Ip

Michael S Krangel

The present invention provides purified polypeptides which comprise at least a portion of a &dgr; T cell receptor polypeptide, a &ggr; T cell receptor polypeptide, a &ggr;, &dgr; T cell receptor complex or a &ggr;, &ggr; T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.

&ggr;, &dgr; T cell receptor and methods for detection

The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .delta. T cell receptor complex or a .gamma., .gamma. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.

.gamma., .delta. T cell receptor and methods for detection

The present invention provides purified polypeptides which comprise at least a portion of a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide, a .gamma., .delta.T cell receptor complex or a .gamma., .gamma.T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.

.GAMMA., .delta.T cell receptor and methods and detection

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Mitlon, MA, United States of America

Johnathan Seidman