The Salk Institute for Biological Studies

The Scripps Research Institute

Icahn School of Medicine at Mount Sinai

Sanford-burnham Medical Research Institute

John Young

Marc Siladi

Mark J Yeager

John M Marlett

Godfrey Jonah Anderson Rainey

Heather M Scobie

Diane Thomas

Anette Schneemann

Marianne Manchester

Kelly Dryden

Darly Joseph Manayani

Vijay Reddy

Peter M Palese

Adolfo Garcia-Sastre

Sumit K Chanda

Megan Shaw

Silke Stertz

Renate König

This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.

Compositions and methods for inhibiting human host factors required for influenza virus replication

Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.

Antitoxin and vaccine platform based on nodavirus VLPS

Antitoxin and vaccine platform based on nodavirus VLPs

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San Diego, CA, United States of America

John Young