William H. Rorer, Inc.

Rorer Pharmaceutical Corporation

John Yelnosky

William L Studt

Donald E Kuhla

Henry F Campbell

George H Douglas

Ghulam N Mir

Chong M Won

Richard L Riley

Billy J Chou

Dahyabhai M Patel

Ronald L Alioto

George A Condouris

1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of Irritable Bowel Syndrome.

Amidinoureas for treating irritable bowel syndrome

Aryl substituted diazaheterocyclic amines and their use in the treatment of gastrointestinal motility dysfunctions.

Aryl substituted heterocycles for treating gastrointestinal motility

Amidinoureas are disclosed as useful for the treatment of irritable bowel syndrome.

A method for treating gastrointestinal motility dysfunctions using phenylheterocyclic guanidines and novel heterocyclic guanidine compounds.

Heterocyclic guanidines for treating gastrointestinal motility

1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of irritable bowel syndrome.

Method for treating gastrointestinal motility dysfunctions using 1,2,4-triazines.

1,2,4-Triazines for treating gastrointestinal motility dysfunction

A method for the treatment of a gastrointestinal motility dysfunction using a nitrogen containing heterocyclyl substituted acetylguanidine.

Guanidine derivatives for treating gastrointestinal motility dysfunction

A method for treating gastrointestinal motility dysfunctions using 2-amino-quinoline and -quinazoline derivatives.

Quinoline and quinazoline derivatives for treating gastrointestinal

A method for the treatment of irritable bowel syndrome using a 1,3,5-triazin-2-one and a class of 6-amino and 6-mercaptyl-1,3,5-triazin-2-one compounds.

Triazinones for treating irritable bowel syndrome

Treatment of coccidiosis

1,4-Disubstituted-1,2-dihydro-1,3,5-triazin-2-ones are used to block conduction of high frequency nerve impulses by selectively acting to substantially completely block high frequency impulses without significantly blocking conduction of a single impulse. The effect is reversible when the drug is withdrawn.

Method for blocking high frequency nerve stimulation

Scours in animals, particularly new-born calves, lambs, piglets and foals are treated with a compound containing an effective amount of an antidiarrheal amidinourea.

Method of treating scours

Multiple daily dosing with amidinoureas of the formula ##STR1## produces a significant and sustained decrease in blood pressure in humans.

Method of lowering blood pressure

New compositions containing as the principle active ingredient a 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-one are used for remedial or prophylactic treatment of diarrhea and organic gastrointestinal disorders accompanied by diarrheal symptoms.

Antidiarrheal triazinones

1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-ones and their pharmaceutically acceptable salts are used in the control of abdominal spasticity especially the treatment of spasmodic conditions of the gastrointestinal tract by administering an effective amount of the triazinone in suitable pharmaceutical dosage forms including oral or parenteral dosage forms compounded with pharmaceutically acceptable carrier materials to patients having spasmodic syndromes.

Growing community of inventors

Warrington, PA, United States of America

John Yelnosky