Commonwealth Scientific and Industrial Research Organisation

University of Georgia Research Foundation, Inc.

Australian Poultry Crc

Australian Poultry Crc Pty Ltd.

John William Lowenthal

Ralph A Tripp

Andrew Bean

Luis Fernando Malaver-Ortega

Michael A Johnson

Jennifer Joy York

Richard J McCoy

Andrew Gerard D Bean

Christopher T Prideaux

Adam Joseph Karpala

Terri Ellen O'Neil

Stephen Rhodes

Matthew Robert Digby

Terri E O'Neil

Terri Ellen O'NEIL

The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.

Production of viruses in cell culture

The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.

Production of viruses in avian eggs

The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon-&#x3bb; (IFN-&#x3bb;) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN-&#x3bb; protein or nucleic acid functionality.

Avian cytokines and genetic sequences encoding same

The present invention provides compositions comprising recombinant avian IFN-&ggr; polypeptides and methods using said recombinant avian IFN-&ggr; polypeptides and compositions to enhance the immune responses of birds, and to enhance growth and/or prevent weight loss in birds. The present invention is particularly useful in the prophylactic and therapeutic treatment of birds against coccidiosis and the causative agent thereof.

Uses of avian interferon gamma (IFN-&ggr;)

This invention relates to a recombinant vector comprising a recombinant avian adenovirus incorporating, and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinate of infectious bursal disease virus. The invention further relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting poultry from disease.

Recombinant avian adenovirus vector

Recombinant avian interferon-gamma (IFN-.gamma.)

Growing community of inventors

Belmont, Australia

John William Lowenthal