Antares Pharma, Inc.

John William Hayes

Paul K Wotton

Peter L Sadowski

Kaushik J Dave

Jonathan Jaffe

Hermanus L Jooste

Peter L Sadowsky

Paul Wotton

Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Hazardous agent injection system

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

Needle assisted jet injection administration of testosterone compositions

A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the C, Tand bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the C, Tand bioavailability of methotrexate delivered by a hand-powered syringe.

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Chaska, MN, United States of America

John William Hayes