Pfizer Corporation

Pfizer Products Inc.

John William Benbow

Jeffrey Allen Pfefferkorn

Meihua Mike Tu

Daniel W Kung

David W Piotrowski

Daniel Wei-Shung Kung

Jihong Lou

Margaret Y Chu-Moyer

Yu Hui

The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R, R, R, and Rare as described herein.

Substituted imidazoles useful for treating type II diabetes

The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. The variables R, R, Rand Rare as described herein.

Substituted pyrazinone amides useful for activation of glucokinase

Substituted imidazole propanamide glucokinase activators

The invention relates to compounds of formula (I) prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein R, R, Rand Rare as defined herein; pharmaceutical compositions thereof; and uses thereof. 

Substituted 2H-[1,2,4]triazolo[4,3-a]pyrazines as GSK-3 inhibitors

The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R, R, and Rare as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof in the treatment of, inter alia, conditions, diseases, and symptoms including, inter alia, Alzheimer's Disease, cancer, dementia, depression, diabetes, hair loss, schizophrenia, and stroke. 

Aminopyrazole derivatives as GSK-3 inhibitors

The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R, n and Rare as described herein; compositions thereof; and uses thereof.

Substituted 3-amino-pyrrolidino-4-lactams

The present invention provides compounds of formula (I) the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein R, R, R, and Rare as defined herein; pharmaceutical compositions thereof; and uses thereof.

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Norwich, CT, United States of America

John William Benbow