Advanced Neuromodulation Systems, Inc.

Micro Helix, Inc.

Optical Data, Inc.

University of Washington

Pi Medical, Inc.

Evanite Fiber Corporation

Industrial Control Development, Inc.

John W Swanson

Jerome J Boogaard

Don Dye

Dave Locke

Terry D Daglow

W Eugene Skiens

Michael A Lind

Ky Huynh

Norman M Hill

Kevin Turner

Lucien M Rucker

John H Erickson

Christopher S L Crawford

Timothy J Cox

Arne H Voie

Ben M Clopton

Francis A Spelman

Enri Zhulati

John S Hartman

Robert W Lucas

Claude N Jolly

Sergey N Varivoda

James Pylant

Andreas N Hadjicostis

Anna Norlin-Weissenrieder

Scott S Corbett, Iii

Thomas R Clary

Stephen L Goldman

Jonathan R Biles

Larry D Vockler

Brian Franz

Jerry Martyniuk

William B Brecht

Clyde D Feyrer

Nancy E Iwamoto

Michael DiGiacomo

Rajasree (Sarah) Das

Thomas E Grigsby

Joseph M Halter

Tom Sosebee

Don L Dye

A method including digital printing a heat curable aqueous composition onto a substrate, wherein the composition includes: (a) at least one water soluble synthetic alkali metal silicate; and (b)(i) at least one pigment or (b)(ii) at least one additive selected from aluminum oxide, ceramic microspheres, recycled ground glass, or calcium carbonate; wherein the composition is substantially free of any organic solvent; and heating the composition bearing substrate thereby curing the composition, and wherein the substrate includes a material selected from glass, ceramic, textile, polymeric, metal, wood, or a combination thereof.

Digital ink

In one embodiment, a neurostimulation lead for stimulating neural tissue of a patient, comprises: a lead body of insulative material; a plurality of electrodes; a plurality of terminals; a plurality of conductors, wherein the plurality of electrodes are electrically coupled to the plurality of terminals through the plurality of conductors; wherein the plurality of conductors are disposed in a helical manner in a repeating pattern of groups of conductors separated by gaps along a substantial length of the lead body, each gap being larger than an inter-conductor pitch within the groups of conductors; wherein the insulative material is a compliant material permitting elongation of the lead at low stretching forces and the insulative material of the lead body is fused through a substantial volume of the lead body and along a substantial length of the lead body.

Compliant electrical stimulation leads and methods of fabrication

In one embodiment, a method of fabrication of a stimulation lead for electrical stimulation of tissue of a patient, the method comprises: providing a substrate of non-conductive material for a stimulation portion of the stimulation lead; processing the substrate to create a plurality of recessed features into a surface of the substrate, wherein the plurality of recessed features comprise a plurality of paths for electrical traces and a plurality of surfaces for electrodes with each of the surfaces being connected to one of the traces; providing first conductive material over the surface of the substrate; subjecting the surface of the substrate to mechanical processing to remove conductive material from portions of the substrate disposed above the plurality of recessed features, wherein each respective connected electrode and trace is electrically isolated from the other electrodes and traces after the mechanical processing; electrically plating second conductive material over the first conductive material; providing insulative material over the plurality of electrical traces; and electrically connecting conductive material of electrical traces with conductor wires of a lead body.

Method of fabricating stimulation lead for applying electrical stimulation to tissue of a patient

In one embodiment, a paddle-style lead for implantation in the epidural space through an insertion tool, the paddle-style lead comprises: a paddle structure that comprises: (i) a frame of rigid material, the frame comprising a spring member adapted to bias the frame to assume a first width and a first length, the frame being adapted to elongate to assume a second width and a second length under application of a compressive force; and (ii) elastic material disposed across an interior surface area defined the frame, wherein a plurality of electrodes and a plurality of electrical traces are provided on the elastic material, wherein the plurality of electrical traces are electrically coupled to a plurality of lead conductors and the plurality of electrodes; wherein the plurality of electrical traces comprises a plurality of alternating curves that elongate when the elastic material is stretched.

Implantable paddle lead comprising stretching electrical traces and method of fabrication

In one embodiment, a method of fabrication of a stimulation lead comprising a plurality of segmented electrodes for stimulation of tissue of a patient, the method comprises: providing an elongated, substantially cylindrical substrate, the substrate comprising a plurality of recesses defined in an outer surface of the substrate; coating the substrate with conductive material; patterning conductive material on the substrate to form a plurality of electrode surfaces for at least the plurality of segmented electrodes and a plurality of traces connected to the plurality of electrode surfaces, wherein each electrode surface and its corresponding trace are defined in the recesses on the outer surface of the substrate and are electrically isolated from other electrode surfaces and traces; providing insulative material over at least the plurality of traces; and electrically coupling the plurality of traces to conductive wires of a lead body.

Method of fabricating a stimulation lead

In one embodiment, a deep brain stimulation (DBS) system for electrically stimulating a target location in the brain of a patient, comprises: pulse generating circuitry for generating electrical pulses; at least one electrical lead for conducting electrical pulses generated by the pulse generating circuitry to the target location using one or several stimulation electrodes, wherein the at least one electrical lead further comprises one or several electrochemical sensors for sensing an extracellular level of one or several neurotransmitters and/or precursors; and a controller for controlling the pulse generating circuitry using closed-loop feedback based upon the extracellular level of the one or several neurotransmitters, wherein the controller for controlling the pulse generating circuitry processes the extracellular level of the one or several neurotransmitters using a measured impedance between one or several of the electrochemical sensors and a reference electrode.

Closed-loop deep brain stimulation system adapted to accommodate glial scarring and method of operation

In one embodiment, an assembly for conducting pulses from an implantable pulse generator, comprises: at least one percutaneous lead comprising terminals and at least two groups of electrodes, each group of electrodes possessing an intra-group electrode spacing; a frame member comprising first and second arms, the frame member comprising an inner lumen for removably housing the at least one percutaneous lead, each arm of the first and second arms comprising a plurality of apertures that are spaced according to the intra-group electrode spacing to allow conduction of electrical pulses from the electrodes of the at least one percutaneous lead to tissue of the patient when the lead is positioned within the frame member; and a spring member that is connected to the frame member for maintaining the first and second arms of the frame member at a predetermined distance in the absence of an external force on the spring member.

Assembly kit for creating paddle-style lead from one or several percutaneous leads and method of lead implantation

In one embodiment, a medical lead comprises a lead body for conducting electrical pulses and a paddle. The paddle includes an intermediate metal layer, at least an insulative polymer backing layer, and an insulative polymer covering layer. The intermediate metal layer comprises a plurality of features defined by gaps in the metal material in the metal layer such that each feature is electrically isolated from each other feature, wherein each feature includes a respective connector element that is electrically coupled to at least one conductor within the lead body, wherein a portion of the insulative polymer covering layer is exposed above each feature to define a respective electrode for the corresponding feature. Also, the paddle possesses shape memory to cause the paddle to assume a substantially planar orientation when the shape memory is in a relaxed state.

Self-folding paddle lead and method of fabricating a paddle lead

In one embodiment, a stimulation lead for applying electrical pulses to tissue of a patient, the stimulation lead comprises: a plurality of electrodes on a first end of the lead body; a plurality of terminals on a second end of the lead body; a lead body comprising a flex film component disposed within insulative material, wherein (i) the flex film component comprises a plurality of electrical traces, (ii) the plurality of electrical traces electrically couple the plurality of electrodes with the plurality of terminals, and (iii) the flex film component comprises a plurality of bends along a substantial length of the lead body; wherein the stimulation lead is adapted to elastically elongate under application of stretching forces to the lead body without disconnection of the electrical connections between the plurality of electrodes and the plurality of terminals through the electrical traces of the flex film component.

Stimulation lead comprising internal flex film component and method of fabrication

Fabricating an implantable stimulation lead by advancing work material to be wrapped with wire conductors, then, operating a plurality of payout carriers to let out the wire conductors, rotating the plurality of payout carriers to wrap the wire conductors about the work material, providing an amount of twist to each wire conductor as the wire conductors are let out, forming a lead body using the wrapped conductors, and fabricating a plurality terminals on the lead body, wherein the plurality of terminals are electrically connected to the conductive wires.

Method for producing a multielectrode lead

In one embodiment, a stimulation system for generating and delivering electrical stimulation pulse to tissue of a patient, comprises: a pulse generator for generating electrical pulses, the pulse generator comprising a housing portion and a header portion with feedthroughs extending from the housing portion into the header portion; and a stimulation lead comprising a flex film component enclosed in a lead body of insulative material, the flex film component including a plurality of electrically isolated conductors extending along a substantial length of the stimulation lead, the stimulation lead further comprising a plurality of electrodes electrically coupled to the conductors, the flex film component comprising a proximal portion that is exposed out of the insulative material of the lead body and includes a plurality of terminal bond bands, the terminal bond bands being electrically coupled to the conductors; and wherein the header portion of the pulse generator comprises a lid component to compress the terminal bond pads of the stimulation lead into electrical contact with conductors of feedthroughs of the pulse generator.

Connector design for implantable pulse generator for neurostimulation, implantable stimulation lead, and methods of fabrication

In one embodiment, a percutaneous stimulation lead for applying electrically stimulation pulses to tissue of the patient comprises: a plurality of electrode assemblies electrically coupled to a plurality of terminals through a plurality of conductors of the stimulation lead, wherein each electrode assembly is disposed in an annular manner around the lead body and each electrode assembly comprises (i) an electrode adapted to deliver electrical stimulation to tissue of a patient, (ii) an interior conductive layer, and (iii) a dielectric layer disposed between the electrode and the interior conductive layer; the electrode and interior conductive layer being capacitively coupled, the dielectric layer further comprising an inductor, the inductor being electrically connected to one of the plurality of conductors through the interior conductive layer, and the inductor being electrically coupled to the electrode.

Method of fabricating a percutaneous stimulation lead

In one embodiment, a method of fabricating a stimulation lead for stimulation of tissue of a patient, the method comprises: providing a plurality of cables, wherein each of the cables comprises a plurality of wires twisted about a core support and disposed within an outer sheath, wherein each of the plurality of wires comprises a coating of insulative material to electrically isolate each wire from each other wire within the respective cable, each of the plurality of wires being disposed in a single layer circumferentially about a central axis of the respective cable; wrapping the plurality of cables about a central core in a helical manner to form a cable assembly.

Method for fabrication of a neurostimulaton lead including multiple micro-cables

In one embodiment, a method, of fabricating a stimulation lead for stimulating tissue of a patient, comprises: providing a lead body, the lead body comprising a plurality of conductors embedded within insulating material; providing a plurality of terminals; electrically coupling the plurality of terminals with the plurality of conductors; providing a plurality of electrodes, the plurality of electrodes comprising a plurality of substantially continuous longitudinal trenches on a surface of the electrodes, the electrodes comprising areas of reflow material forming microstructures substantially continuously along walls of the longitudinal trenches; and electrically coupling the plurality of electrodes with the plurality of conductors.

Method for processing electrodes for stimulation lead

In one embodiment, a method of fabricating an implantable stimulation paddle comprises: providing a sheet of conductive material coupled to a first insulative layer; laser removing portions of the conductive material to form a pattern of conductive material, the pattern of conductive material including a plurality of isolated metal traces; providing a second insulative layer over the pattern of conductive material so that the pattern of conductive material is interposed between the first and second insulative layers; and exposing portions of the metal traces to form electrodes on the paddle for delivering electrical stimulation.

Spinal cord stimulation paddle lead and method of making the same

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Lake Oswego, OR, United States of America

John W Swanson