3m Innovative Properties Company

Elan Pharmaceuticals, Inc.

Other

Graceway Pharmaceuticals, LLC

Pharmacia & Upjohn Company

John W Mickelson

Bryon A Merrill

Michael J Rice

Kyle J Lindstrom

John F Gerster

Gregory J Marszalek

Philip D Heppner

Stephen L Crooks

Peter V Maye

Joseph F Dellaria, Jr

Leslie J Charles

Andrea Gailunas

John Nicholas Freskos

Varghese John

Ruth Elizabeth TenBrink

Roy K Hom

James Beck

Barbara Jagodzinska

Michel Maillard

Lakshman Samala

George W Griesgraber

Lawrence Y Fang

John Alan Tucker

Paul G Gassman

Karl J Manske

Jennifer Sealy

Larry Fang

Ruth Tenbrink

Jennifer Sealey

Adam Stolt

Phillip D Heppner

John R Sowa

A portable plant, systems and methods for processing material, the plant having a chassis configured to connect to a truck to transport the plant on a roadway, the chassis having wheels and a base frame, an uppermost portion of the base frame positioned below an uppermost portion of the wheels, a first material processing device such as a hydrosizer mounted to a tower structure, the tower structure rotatably fixed to the base frame, and a hydraulic cylinder connected to the base frame and to the tower structure where operation of the cylinder causes the hydrosizer and the tower to adjust between a generally horizontal orientation where the hydrosizer is generally horizonatally oriented or rests on the base frame and a generally vertical orientation. The hydrosizer may be a cone-shaped hydrosizer and the wheels may be associated with a removable suspension and the chassis is configured to rest on the ground and receive additional processing components for use in a processing mode where the additional components are placed on a position of the chassis vacated by the elevated first material processing device.

Portable sand plant, systems and methods

Disclosed are compounds of the formula wherein the variables R, R, R, R, R, and Rare as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.

N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

Intermediates for imidazonaphthyridines

Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds

Disclosed are compounds of the formula wherein the variables R, R, R, R, R, and Rare as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Imidazonaphthyridines

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Aryl ether substituted imidazoquinolines

Thiazolo-, oxazolo- and selenazolo&lsqb;4,5-c&rsqb;quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Oxazolo, thiazolo and selenazolo &lsqb;4,5-C&rsqb;-quinolin-4-amines and analogs thereof

Oxazolo, thiazolo and selenazolo &lsqb;4,5-c&rsqb;-quinolin-4-amines and analogs thereof

Growing community of inventors

North St. Paul, MN, United States of America

John W Mickelson