Eastman-kodak Company

Carestream Health, Inc.

Bruker Biospin Gmbh

John W Harder

Stephen P Singer

Paul A Burns

Rakesh Jain

William J Begley

J Ramon Vargas

Leslie Shuttleworth

Hans G Ling

Arlyce T Bowne

William B Vreeland

James Stephen Honan

Paul L Zengerle

Albert J Mura, Jr

James Henry Reynolds

Drake M Michno

Robert F Romanet

David A Stegman

William J Harrison

Teh-Hsuan Chen

Ruizheng Wang

Steven P Szatynski

Michael Phillip Youngblood

Hans F Schmitthenner

Gregory J Lestina

Phillip D Knight

Tao Ji

Lynda D Weber

Jon D Bass

Roger L Lok

Joseph F Bringley

Stanley W Cowan

Jeffrey W Leon

Harold C Warren

Tiecheng A Qiao

Louis Elbert Friedrich

Douglas Lincoln Vizard

Christopher T Brown

David S Ross

Paul P Spara

John C Mauck

Janet N Younathan

James R Bennett

William E McLaughlin

Scott R Conley

Raymond P Scaringe

Robert C Stewart

John V Nelson

John D Baloga

Brian J Kelley

Carl R Preddy

Rao Papineni

Peter R Seoane

Christopher W Grote

Ileana Place

Andrew Wunder

James M Hewitt

Yonghong Yang

Philip D Knight

The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes

A combination of nanoparticles is disclosed comprised of amine functionalized polyethylene glycol in which one particle with a fluorescent donor dye having one wavelength excitation maximum and at least one additional particle with a second fluorescent dye having a second, higher wavelength excitation maximum, the particles having the same or different biomolecule targeting moieties bound to their external surfaces.

Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications

The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Large stoke shift dye used for optical imaging

Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed magenta dye that is present in an amount to provide a status M green density greater than 0.005 per mg/m. This dye provides minimum density at lower cost and enables lower dye levels and a reduced organic load that may lead to improved film physical properties.

Color photographic materials with magenta minimum density dyes

Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed yellow colorant that is present in an amount to provide a status M blue density greater than 0.003 per mg/m. This colorant provides minimum density at lower cost and can be incorporated with minimal or no organic solvents and thus enable a reduced organic load that may lead to improved film physical properties.

Color photographic materials with yellow minimum density colorants

The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .&#x3bc;mol amine-monomer/g core particles.

Amine polymer-modified nanoparticulate carriers

This invention relates to a multilayer silver halide photographic element, generally processed with phenylenediamine based developer solutions, comprising a support bearing a cyan dye image-forming unit comprised of at least one red-sensitive silver halide emulsion layer having associated therewith at least one cyan dye-forming coupler, a magenta dye image-forming unit comprising at least one green-sensitive silver halide emulsion layer having associated therewith at least one magenta dye-forming coupler, and a yellow dye image-forming unit comprising at least one blue-sensitive silver halide emulsion layer having associated therewith at least one yellow dye-forming coupler, wherein at least one layer additionally contains a 2-substituted-5-amino-1-napthol DIR according to Formula (I): wherein: It has been found that such 2-substituted-5-amino-1-napthol based DIRs have improved properties and can provide a conventional silver halide photographic element with excellent image structure and color reproduction.

Photographic material with improved development inhibitor releases

Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-&lsqb;1,2,4&rsqb;-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than &minus;0.16V and less than &plus;1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.

Synthesis of certain triazole compounds

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a bicyclic azole dye-forming coupler compound having Formula I:

Photographic element and compound and process useful therewith

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a cyan dye-forming coupler represented by Formula (I):

Photographic element containing nitrogen heterocycle substituted cyan coupler and process

Disclosed is a photographic element complising a light sensitive silver halide emulsion layer having associated therewith a cyan dye forming coupler having Formula (I):

Photographic element, dispersion, compound and process

Disclosed is a photographic element comprising at least one light sensitive silver halide emulsion layer having associated therewith: (A) a phenolic cyan dye-forming 'NB coupler';

Cyan coupler, and stabilizer-containing photographic element and process

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a certain magenta dye forming coupler and a light-sensitive silver halide emulsion layer having associated therewith a certain yellow dye-forming coupler. The element exhibits improved dye fade and equal or better red color gamut than that obtained using comparisons.

Magenta and yellow coupler combination in silver halide photographic

Disclosed is a photographic element comprising a light sensitive silver halide emulsion layer having in association therewith at least one dye- forming coupler of Formula (1a): ##STR1## wherein: R.sub.1 is an alpha-branched alkyl group with greater than 10 carbon atoms;

Photographic element and process for its use

Disclosed is a photographic element comprising a support on which is coated at least one green-sensitized silver halide emulsion layer having associated therewith at least one magenta dye-forming coupler of Formula I ##STR1## wherein: R.sub.1 is an alkyl group;

Photographic element with particular magenta coupler

Growing community of inventors

Rochester, NY, United States of America

John W Harder