University Technologies International, Inc.

Her Majesty the Queen in Right of the Province of Alberta, As

John W Costerton

Frank Johnson

Antoine E Khoury

A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in planktonic form. The effect of the biocide is potentiated, to an effective killing level, by applying an electric field across the surface containing the biofilm.

Biofilm reduction method

A method is provided for removing biofilm from a surface submerged in water. The method includes cooling the biofilm to below the freezing point of water to thereby generate large, sharp-edged ice crystals in the biofilm. The frozen biofilm is then thawed and removed from the surface by, for instance, flowing a liquid across the surface.

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Calgary, Canada

John W Costerton