Harbor Branch Oceanographic Institution, Inc.

Pharma Mar, S.a.

The United States of America As Represented by the Secretary of

The United States of America As Represented by the Department of Health

John W Blunt

Murray H Munro

Nigel B Perry

Michael R Boyd

Dolores Garcia Gravalos

James Brislin McMahon

Gerhard Bringmann

John H Cardellina, Ii

Gordon M Cragg

Lewis K Pannell

Kirk P Manfredi

Robert J Gulakowski

Duncan Thomas

Johnson Jato

Sylvia Urban

Andrew M Thompson

Murray Herbert Gibson Munro

Marc S Litaudon

Robin J Lake

The invention provides a compound of formula (I). This invention relates to heterocyclic compounds. It further relates to methods for their preparation, compositions cotaining them and their use as a medicament, particularly as a medicament for the treatment and prophylaxis of cancer. 

Antitumoral carbazoles

Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R.sup.1 and R.sup.2 together form a spiro attached ring system selected from the group consisting of: ##STR2##

Halichondrins

The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.

Process of preparing michellamine compounds

Michellamine antiviral agents, compositions, and treatment methods

A new biologically active compound discorhabdin D, pharmaceutical compositions containing same, methods of producing the compound and compositions and methods of using them are disclosed. The new compound, discorhabdin D, has the structure: ##STR1##

Discorhabdin D, compositions containing same and methods of preparatio

Mycalamide compounds are derived from marine sponges of the genus Mycale or prepared by synthetic methods. These compounds and pharmaceutical compositions containing them as active ingredients are useful as antitumor and antiviral agents.

Mycalamide compounds, compositions thereof and methods of preparation

This invention relates to novel discorhabdin compositions which are useful as antitumor, antibacterial and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, bacteria and fungi utilizing the compositions. More particularly, the novel discorhabdin compositions are organic compounds which are derived from marine sponges genus Latrunculia.

Discorhabdin compositions and their methods of use

Growing community of inventors

Christchurch, New Zealand

John W Blunt