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Medical University of South Carolina

Kansas University Medical Center

Kansas University Medical Center Research Institute Inc.

John W Baynes

Billy G Hudson

Raja Gabriel Khalifah

Suzanne R Thorpe

Nathan Alderson

Thorsten P Degenhardt

Joelle Onorato

A method for treating diabetic neuropathy is disclosed consisting of administering pyridoxamine or a salt thereof.

Methods for treating diabetic neuropathy

The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches methods to treat or prevent diabetes associated hyperlipidemia, cellular redox imbalances, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis, comprising administering the compounds of the invention to a mammal in need thereof.

Methods for inhibiting diabetic complications

The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches new methods to treat or prevent oxidative modification of proteins, including low density lipoproteins, to treat or prevent lipid peroxidation, and to treat or prevent atherosclerosis, comprising administering an amount effective of one of the compounds of the invention to treat or prevent the disorder.

Methods for inhibiting oxidative modification of proteins

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Columbia, SC, United States of America

John W Baynes