Applied Research Systems Ars Holding N.v.

Ares-serono Research & Development Limited Partnership

John Attridge

Simon Degroot

Stephen W. Eason

John W Attridge

Grenville Arthur Robinson

Phelim Brinley Daniels

Julie Karen Deacon

Colin Andrew Love

Aileen Margaret Thomson

Stephen William Eason

Alan M Smith

A method of assay for a ligand in a sample is described in which calibration occurs within the assay. This is achieved utilizing a measurement region and one or more calibration regions. In at least one of the calibration regions a non-zero signal results, either because of the presence of a calibration reagent or as a result of a binding reaction analogous to that which takes place in the measurement region.

Capillary-fill biosensor device comprising a calibration zone

Sensor devices for use in assaying for a substance selected from (i) enzymes capable of producing a change in their environment as a result of catalytic reaction with a substrate and (ii) substrates for such enzymes is described, the devices comprising an optical waveguide having immobilized directly or indirectly on a discrete region ('the measurement region') of one longitudinal surface thereof a species whose optical properties change as a result of the aforementioned change in its environment together with the member of an enzyme substrate/enzyme pair complementary to the substance under assay. Methods of assay using such devices are also described.

Optical sensor for enzyme and enzyme substrates

A method of assay for a ligand in a sample is described in which calibration occurs within the assay. This is achieved utilizing a measurement region and one ore more calibration regions. In at least one of the calibration regions a non-zero signal results, either because of the presence of a calibration reagent or as a result of a binding reaction analogous to that which takes place in the measurement region.

Method of assay having calibration within the assay

Method for improving measurement precision in evanescent wave optical

Optical waveguide assay unit and method of improving assay sensitivity

Fluorescent assay and sensor therefor

Devices for use in chemical test procedures

Multianalyte test vehicle

Method of optical analysis of a fluid including an optical waveguide

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Weybridge, United Kingdom

John W Attridge