The Florida State University Research Foundation, Inc.

University College Cardiff Consultants Limited

Inhibitex, Inc.

John Vernachio

Stanley Dawes Chamberlain

Richard K Plemper

Eddy Lee

Elyse Bourque

Karolina Madela

Christopher McGuigan

Jeff T Hutchins

Chris McGuigan

Mohamed Aljarah

Arnaud Gilles

Claire Bourdin

Richard Plemper

Disclosed herein are compounds and compositions for treating or inhibiting RSV and related members of the pneumovirus and paramyxovirus families such as human metapneumovirus, mumps virus, human parainfluenzaviruses, and Nipah and hendra virus, and methods of treatment or prevention thereof.

Heterocyclic derivatives for the treatment of RSV

Bicyclic fused pyrazole derivatives for the treatment of RSV

This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structure wherein U, V, W, Z, R, X, X, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular.

Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections

Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections

Growing community of inventors

Alpharetta, GA, United States of America

John Vernachio