Abbott Diabetes Care Inc.

Lawrence Livermore National Security, LLC

John V LaTour

Udo Hoss

Tianmei Ouyang

Kevin Paul Wallis

Benjamin J Feldman

Suyue Qian

Stephen Oja

Jonathan D Mccanless

Phu X Le

Balasubrahmanya S Bommakanti

Gary Sandhu

Amy L Gryshuk

Julie Perkins

Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.

Analyte sensors and sensing methods featuring low-potential detection

Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.

Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.

Temperature-insensitive membrane materials and analyte sensors containing the same

Methods and systems to generate 6-amino-6-deoxy--luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives.

Methods and systems for synthesis of a D-aminoluciferin precursor and related compounds

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Alameda, CA, United States of America

John V LaTour