Dade International Inc.

Novilux, LLC

University of California

Singulex, Inc.

John Todd

Richard A Livingston

Philippe J Goix

Robert Puskas

Douglas Held

Patrick J Sheridan

Allan H B Wu

Priscilla Wilkins Stevens

Terukatsu Arima

Badr Saeed

Terence E Ryan

Robert E Byrne

Mark K Kieselburg

David G Kern

Alan H Wu

The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Highly sensitive system and method for analysis of troponin

A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.

DNA sequence and encoded polypeptide useful in the diagnosis of

This invention utilizes beads in sample preparation to increase the precision of nucleotide hybridization assays.

Use of beads to improve nucleotide hybridization assays

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LaFayette, CA, United States of America

John Todd