Sio2 Medical Products, Inc.

The Boc Group, Inc.

Nanoscale Surface Systems, Inc.

Other

Universal Display Corporation

Krones Ag

Applied Materials, Inc.

Aviza Technology Limited

Asml Us, Inc.

Cv Holdings LLC

Silcon Valley Group Thermal Systems, LLC

Si02 Medical Products, Inc.

John Thomas Felts

Thomas E Fisk

Christopher Weikart

Peter J Sagona

Robert S Abrams

John Ferguson

Robert J Pangborn

Jonathan R Freedman

Adam Stevenson

Becky L Clark

Peter Rose

Eugene Lopata

Ruiqing Ma

Julia J Brown

Prashant Mandlik

Jeffrey Silvernail

Jochen Krueger

Ahmad Taha

Joseph Countrywood

Eugene S Lopata

Robert J Nelson

Hood Chatham, Iii

Jean-Pierre Giraud

Herve Pichot

Emory Krall

Heinz Humele

Bruce Rabinne

Jacob N Israelachvili

Benjamin Hunt

Andreas Kraus

Tadashi Yamamoto

Brian Russell Lilly

Andreas Kursawe

Joseph A Jones

James J Hofmann

Brian Fitzpatrick

Jeff Silvernail

Shawn Kinney

Christopher John Felts

John Berggren

Johathan R Freedman

Robert R Hoffman

James Troy Gresham

Zhaoqun Zhoi

Adrian Raiche

Jochen Krüger

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOcomposite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O—Si—C covalent bonding, as a proportion of the O—Si—C covalent bonding plus SiObonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiObonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

SiObarrier for pharmaceutical package and coating process

An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

PECVD coated pharmaceutical packaging

A substrate is described having a treated contact surface comprising a carbon or silicon compound comprising from 1 to 30 atomic percent oxygen, from 0.1 to 30 atomic percent nitrogen, or both, each as measured by XPS. A method is also provided for treating a surface of a substrate. The method includes treating the surface with plasma comprising one or more non-polymerizing compounds. The treated contact surface has a biomolecule recovery percentage greater than the biomolecule recovery percentage of the surface prior to treatment according to the method.

Polymeric surface having reduced biomolecule adhesion to thermoplastic articles and methods of plasma treatment

A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the Oto the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus

A method of forming microelectronic systems on a flexible substrate includes depositing a plurality of layers on one side of the flexible substrate. Each of the plurality of layers is deposited from one of a plurality of sources. A vertical projection of a perimeter of each one of the plurality of sources does not intersect the flexible substrate. The flexible substrate is in motion during the depositing the plurality of layers via a roll to roll feed and retrieval system.

Manufacturing flexible organic electronic devices

A syringe or other vessel having a substrate surface coated by PECVD is provided. The PECVD coating is made by generating plasma from a gaseous reactant comprising an organosilicon precursor and optionally O. The lubricity, hydrophobicity and/or barrier properties of the coating are set by setting the ratio of the Oto the organosilicon precursor in the gaseous reactant, and/or by setting the electric power used for generating the plasma. In particular, a lubricity coating made by said method is provided. Vessels coated by said method and the use of such vessels protecting a compound or composition contained or received in said coated vessel against mechanical and/or chemical effects of the surface of the uncoated vessel material are also provided.

Syringe with PECVD lubrication

A vessel has an interior surface facing a lumen. The interior surface includes a tie coating or layer, a barrier coating or layer, and a pH protective coating or layer. The tie coating or layer can comprise SiOCor SiNC, where x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3. The barrier coating or layer can comprise SiO, wherein x is from 1.5 to 2.9. The barrier coating or layer reduces the ingress of atmospheric gas into the lumen. The pH protective coating or layer can comprise SiOCor SiNC, as well. In an embodiment, in the presence of a fluid composition contained in the lumen and having a pH between 5 and 9, the calculated shelf life of the package can be more than six months at a storage temperature of 4&#xb0; C.

Coated packaging

A substrate is described having a treated contact surface comprising a carbon or silicon compound comprising from 1 to 30 atomic percent oxygen, from 0.1 to 30 atomic percent nitrogen, or both, each as measured by XPS. The treated contact surface has a biomolecule recovery percentage greater than the biomolecule recovery percentage of the surface before treatment according to the method.

Polymeric surface having reduced biomolecule adhesion to thermoplastic articles of such substrate

A package including a vessel wherein at least a portion of the vessel wall is made of a double wall material is disclosed. The double wall material comprises an interior polymer layer enclosed by an exterior polymer layer and one of the polymer layers is a layer made of cyclic olefin polymer (COP) resin. The package comprising the double wall, a CVD coating set on the wall, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

Cyclic olefin polymer vessels and vessel coating methods

A blood sample collection tube and other vessels are described including an article surface and a coating set comprising a tie coating or layer of SiOxCy or SiNxCy applied to the article surface, a barrier coating or layer of SiOx, and a pH protective layer of SiOxCy or SiNxCy. The vessels optionally contain a fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating or layer and pH protective coating or layer together protect the barrier layer from the contents of the vessel.

Blood sample collection tube

A method of reducing static charge of a plastic container is provided. The method includes providing a PECVD coating of SiCOH, SiOor SiOH to an external support surface of the container. The PECVD coating reduces static charge of the container compared to a reference container that is essentially identical to the container except that the reference container is uncoated.

Antistatic coatings for plastic vessels

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Alameda, CA, United States of America

John Thomas Felts