City of Hope

John Termini

Timothy W Synold

Samuel Rahbar

Gerald Wuenschell

Daniel Tamae

Miro Rusnak

Sarah Shuck

Timothy R O'Connor

Yin S Chan

Methods of quantifying a N-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and N-(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

Methods of quantifying methylglyoxal-induced nucleic acid adducts

Methods of quantifying N-carboxyethyl-2'-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

Methods of quantifying N-(1-carboxyethyl)-2'-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG

Methods of quantifying a N-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

A liner or pad is configured to be positioned on a bottom surface of a metabolic cage or to form a bottom of a metabolic cage so as to provide a surface that comfortably supports a confined animal in the cage. The pad provides a surface that prevents the mouse from directly contacting the wire mesh bottom of the cage.

Metabolic cage liner

Methods of quantifying a N-carboxyethyl-2'-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

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John Termini