Avantec Vascular Corporation

Applied Medical Resources Corporation

Origin Medsystems, Inc.

John T To

John D Davis

Thomas A Kramer

Paul Quentin Escudero

Tim J Kovac

Bryan E Loomas

Ryan M Hoshino

John P Lunsford

Charles Gresl, Jr

Teresa Ruvalcaba

Sith Khoune

Jennifer Huynh

Hidenori Yamaguchi

Bryan Duenas

Maria Cruz

Tomoaki Hirose

Vascular cutter devices, systems, and methods are provided to effectively cut and remove all types of thrombus and atheroma tissue, whether soft, tough, or hard, and can do so with a reduced risk of suffering vessel injuries while avoiding an undesirable volume of blood loss during procedures. Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis; and (iv) effectively reduce blood loss during a procedure.

Cutters with pulsating vacuum control

Telescoping, self-driving, and laterally-pushing atherectomy devices are provided, each having a flexible sheath, a cutter with helical flutes, and a drive assembly. The drive assembly can have a flexible driveshaft rotatably translational with the lumen of the flexible sheath, a positive displacement pump to transport cut tissue, and a flexible drive shaft that can be longer than the flexible sheath for a reversible telescoping of the drive assembly from the lumen of the flexible sheath. The positive displacement pump can be a screw pump having a drive screw portion exposed for contact with a vascular lumen for a self-driving of the device through the vascular lumen. A reversibly-expandable, lateral pushing member can be included at the distal end of the flexible sheath for a lateral pushing of the cutter. Improved cutting heads, and methods of making them, are provided for cutting a combination of soft and hard plaque.

Hybrid atherectomy devices

Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.

Thrombectomy devices with lateral and vertical bias

Disclosed are example embodiments of an endovascular coil having a twistedshape. The endovascular coil includes: a first loop; a second loop; and an inflection region where a portion of the first loop transitions into a portion of the second loop. The second loop is rotated about an axis parallel to the longitudinal axis of the first loop to create the twistedshape. The twist adds more randomness and variability to the filling behavior of the endovascular coil. The added randomness and variability enables the twistedcoil to better fill the void of irregular-shaped aneurysms than other conventional embolic coils.

Endovascular coil and method for making the same

Telescoping, self-driving, and laterally-pushing atherectomy devices are provided, each having a flexible sheath, a cutter with helical flutes, and a drive assembly. The drive assembly can have a flexible driveshaft that is rotatably translational with the lumen of the flexible sheath, a positive displacement pump that begins pumping at the distal end of the drive shaft adjacent to the helical flutes at the proximal end of the cutter, and the flexible drive shaft can be longer than the flexible sheath to enable a reversible telescoping of the drive assembly from the lumen of the flexible sheath. The positive displacement pump can be a screw pump having a drive screw portion extending beyond the flexible sheath, exposed for contact with a vascular lumen for the self-driving. And, the devices can have a reversibly-expandable, lateral pushing member at the distal end of the flexible sheath for the lateral pushing.

Telescoping atherectomy device

An embolic device and a corresponding embolic device delivery system and method. In one example, an embolic device delivery system comprises a delivery catheter, a coupler disposed inside the delivery catheter, and an embolic device that may be carried and placed by the coupler. The embolic device includes a primary winding that forms a hollow tube such that a coupler may be threaded therethrough. Further, the embolic device may include a slotted metal tube suited to be affixed to one end of the hollow tube formed by the primary winding. Additionally, the embolic device may include a retaining mechanism that includes one or more protrusions suited to engage with one or more slots of the slotted metal tube. In this manner, the retaining mechanism is affixed to the slotted metal tube and the hollow tube formed by the primary winding.

Embolic device suited for ease of delivery and placement

Atherectomy devices that are self-driving with controlled deflection

A disposable seal assembly for use with a reusable cannula, where the seal assembly is designed for use with the cannula during a single medical procedure and the cannula is designed for multiple uses (each time with a different seal assembly) during a number of medical procedures. The seal assembly includes both a flapper valve fluid seal (for sealing the cannula when no medical instrument is inserted through the seal assembly) and at least one instrument seal (for sealing the cannula when a medical instrument is inserted through the seal assembly). Preferably, the seal assembly has a body with a flange which can be snapped onto the cannula before use, and readily removed after use. Also preferably, the flapper valve has an over-centered hinge. In other embodiments, the invention is a seal assembly which includes at least one double instrument seal including a sacrificial flange and a sealing flange, and optionally also a flapper valve. The sealing flange seals the cannula when a medical instrument is inserted through the seal assembly even when the sacrificial flange has been cut during insertion of the instrument. In other embodiments, the invention is a system including a reusable cannula, and a disposable seal assembly of any of the described types which can be snapped onto the cannula before use and readily removed after use.

Reusable cannula with disposable seal

A disposable seal assembly for use with a reusable cannula preferably includes a flapper valve fluid seal and at least one instrument seal. The instrument seal has a sacrificial flange and a sealing flange that protrude from an inner baffle connected to the assembly's main body by a flexible outer baffle, and at least one elastomeric rib extending between the inner baffle and the body to prevent inversion of the inner baffle. Preferably, a surface of the sacrificial flange is configured to prevent the flanges from sticking together during use. An adaptor, tethered to the assembly's main body, has a central channel with an hourglass profile, a concave distal flange, distal bumpers for preventing the adaptor from translating too far into the main body, and a grip portion shaped to allow a user conveniently to separate the adaptor from the main body. Other aspects include systems with a reusable cannula, and methods for using such systems.

Growing community of inventors

Sunnyvale, CA, United States of America

John T To