University of Pennsylvania

Torqur Ag

Torqur

John T Seykora

Paul Hebeisen

Doriano Fabbro

Florent Beaufils

Petra Hillmann-Wuellner

Anton Stuetz

The present invention is relates to a compound of formula (I), wherein X, Xand Xare, independently of each other, N or CH; with the proviso that at least two of XXand Xare N; Y is N or CH; W is H or F; with the proviso that when W is F, then X, Xand Xare N; Rand Rare independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein Rand Rare independently of each other H, C-Calkyl optionally substituted with one or two OH, C-Cfluoroalkyl, C-Calkoxy, C1alkoxyC-Calkyl, CN, or C(O)O—C-Calkyl; or Rand Rform together a bivalent residue —RR— selected from C-Calkylene optionally substituted with 1 to 4 F, —CH—O—CH—, —CH—NH—CH—, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R; wherein Ris independently at each occurrence C-Calkyl optionally substituted with one or two OH, C-Cfluoroalkyl, C-CalkoxyC-Calkyl, C-Ccycloalkyl; or two Rsubstituents form together a bivalent residue-RR— selected from Ci-C3alkylene optionally substituted with 1 to 4 F, —CH—O—CH— or —O—CHCH—O—; with the proviso that at least one of Randis a morpholinyl of formula II; and prodrugs, metabolites, tautomers, solvates and pharmaceutically acceptable salts thereof, for use in the prevention or treatment of a skin lesion in a subject.

Treatment of skin lesions

The present invention is relates to a compound of formula (I), wherein wherein the arrow denotes the bond in formula (I); andwherein Rand Rare independently of each other H, C-Calkyl optionally substituted with one or two OH, C-Cfluoroalkyl, C-Calkoxy, C-CalkoxyC-Calkyl, CN, or C(O)O&#x2014;C-Calkyl; or Rand Rform together a bivalent residue &#x2014;RR&#x2014; selected from C-Calkylene optionally substituted with 1 to 4 F, &#x2014;CH&#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;NH&#x2014;CH&#x2014;, or any of the structures wherein the arrows denote the bonds in formula (II); or

The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a related compound to treat pre-cancerous skin lesions, skin tumors, and their associated diseases or disorders.

Growing community of inventors

Broomall, PA, United States of America

John T Seykora