The University of Texas System

William Marsh Rice University

Northwestern University

Electric Power Research Institute Incorporated

Labnow, Inc.

John T McDevitt

Eric V Anslyn

Dean P Neikirk

Jason B Shear

Pierre N Floriano

Nick J Christodoulides

Nicolaos J Christodoulides

Karri Lynn Ballard

Chad A Mirkin

John B Goodenough

David Carl Jurbergs

Damon Vincent Borich

Bruce Bernard

Glen Simmons

Paul Speight

Nicolaos Christodoulidies

Tim Abram

Glennon Simmons

Gary N Douglas

Patrick E Rogers

Glenn Simmons

Martin Thornhill

Spencer Redding

JiPing Zhou

Ahmed Haque

Jianai Zhao

Nadarajah Vigneswaran

Ji-Ping Zhou

Michael McRae

Craig Murdoch

Ian Thompson

This disclosure describes the design and function of a bead-based lab-on-a-chip portable analyzer for analyzing biomarker assay cards used in point-of-care testing.

Integrated instrumentation for the analysis of biofluids at the point-of-care

A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid.

Bio-nano-chips for on-site drug screening

The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.

Prostate cancer point of care diagnostics

A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected.

Oral cancer point of care diagnostics

A bionanochip cartridge for analysis of multiple samples or analytes is provided herein, and the cartridge is dimensioned to take advantage of existing robotic microtiter plate handling equipment. Fluidics are specially designed to provide a small footprint and to prevent cross contamination.

Multisample bionanochip platform

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

Methods and compositions related to determination and use of white blood cell counts

A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

Method and system for the detection of cardiac risk factors

Integration of fluids and reagents into self-contained cartridges containing sensor elements

Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems

Particle on membrane assay system

A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

Method and system for the analysis of saliva using a sensor array

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

Fluid based analysis of multiple analytes by a sensor array

Portable sensor array system

Method and apparatus for the delivery of samples to a chemical sensor array

Growing community of inventors

Austin, TX, United States of America

John T McDevitt