Princeton University

University of Virginia Patent Foundation

John T Groves

Roy Xiao

Thomas Brent Gunnoe

Suzanne M Moeller

Xiongyi Huang

George Fortman

Nicholas C Boaz

Thomas P Umile

Anthony Sauve

Marcella Bonchio

Tommaso Carofiglio

Xinyi Chen

Wei Liu

Micah T Nelp

A method and compositions of matter for treating or preventing an auto-immune disorder or immune response in a patient, that includes providing a therapeutic dose to the patient of a substituted indole compound having at least one substitution, wherein the substituted indole compound has only one thiol group, and wherein the ring the thiol group is attached to only contains one N or O atom.

Method and compounds for treating or preventing autoimmune disorders or immune responses modulated by the expression of IDO1

Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClOto at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.

Porphyrazines as efficient, catalytic and scalable method to produce chlorine dioxide

Iron porphyrazines as efficient, catalytic and scalable method to produce chlorine dioxide

Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.

Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation

Methods of C&#x2014;H bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an spC&#x2014;H bond and a fluorinating agent and converting the spC&#x2014;H bond to a C&#x2014;F bond in the presence of the non-heme manganese catalyst or a derivative thereof.

Isotopic fluorination and applications thereof

Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like. Systems and methods as described herein can utilize photocatalysis.

Compositions and methods for hydrocarbon functionalization

Methods of halogenating a carbon containing compound having an sp3 C&#x2014;H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C&#x2014;H fluorination of a carbon containing compound having an sp3 C&#x2014;H bond are provided. The halogenated products of the methods are provided.

C-halogen bond formation

Methods, kits, cartridges and compounds related to generating chlorine dioxide by exposing ClOto at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described. Methods, kits, cartridges and compounds related to decomposed cyanide ions and hydrogen cyanide for water decontamination.

Efficient, manganese catalyzed process to decompose cyanide ions and hydrogen cyanide for water decontamination

Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like.

Methods, kits, cartridges and compounds related to generating chlorine dioxide by exposing ClOto at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described.

Efficient, catalytic and scalable method to produce chlorine dioxide

Assays for the identification of antibacterial agents that inhibit mycobacterial growth by interfering with the iron acquisition pathway in host cells are disclosed. Also disclosed are methods of inhibiting mycobacterial growth by interfering with iron uptake or by delivering antibacterial agents to mycobacteria in host cells through the iron uptake pathway, as well as certain compounds that are useful in the assay methods, and also as antibacterial agents.

Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells

This invention provides a novel class of substituted macrocyclic metallic compounds. The compounds are useful as peroxynitrite decomposition catalysts. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof are also described. 

Porphyrin catalysts and methods of use thereof

This invention provides a novel class of substituted macrocyclic porphyrin compounds. The compounds are useful as peroxynitrite decomposition catalysts. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof are also described.

Growing community of inventors

Princeton, NJ, United States of America

John T Groves