The Cleveland Clinic Foundation

Other

John T Gale

Jorge A Gonzalez-Martinez

Imad Najm

Hyun-Joo Park

Matthew Johnson

Karl West

Andre G Machado

Anthony Shawan

Susan Thompson

Shawan J Anthony

This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

Stereo-thermo-lesioning to treat a patient's neurological condition

This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.

Systems and methods for creating one or more lesions in neurological tissue

The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.

Systems and methods for safe, precise stereotactic implantation

One aspect of the present disclosure relates to a stereotactic guide assembly comprising an implantable body and a fastener. The implantable body can have an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber. At least a portion of the interior chamber can be defined by a first coupling feature. The fastener can be configured to fit in the interior chamber. The fastener can have a second passageway extending therethrough, and a second coupling feature adapted to releasably engage the first coupling feature.

Stereotactic guide assemblies and methods of using same

One aspect of the present disclosure relates a system that can employ micromagnetic stimulation to activate or suppress one or more areas of the central nervous system. A portion of the central nervous system can be exposed. A probe can be configured to be located in proximity to the exposed portion of the nervous system. A microcoil (of a size less than or equal to 10 millimeters) can be coupled to the probe and configured to activate or suppress the portion of the central nervous system via electromagnetic induction.

System and method for micromagnetic stimulation of the central nervous system

One aspect of the present disclosure relates a system that can employ micromagnetic stimulation to activate and/or suppress conduction in at least a portion of a peripheral nerve. The system can include a stimulator to provide a time-varying stimulus. The system can also include a microcoil that can be operatively coupled to the stimulator to receive the time-varying stimulus. Based on the time-varying stimulus, the microcoil can provide an electromagnetic induction to the peripheral nerve to activate and/or suppress conduction.

System and method for micromagnetic stimulation of the peripheral nervous system

The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. The microelectronic circuit can transmit a sequence comprising a label corresponding to the electrical element. The acquisition system can assign the label corresponding to the electrical element to a recording channel after decoding the sequence.

Systems and methods for automated electrical element addressing

A moisture removal assembly designed to be mounted on a brake shoe and pad structure of the rim engaging or caliper type brake assembly comprising a base designed to be removably attached to the brake shoe and a wiper blade structure depending from the base in spaced apart relation from the leading edge of the brake shoe and pad and further being disposed in sliding, wiping engagement with the surface of the rim engaged by the brake pad so as to remove moisture therefrom prior to braking engagement between the wheel rim and brake pad.

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Chardon, OH, United States of America

John T Gale